Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Investigation of the Effect of Inhibition of CYP3A4/5 by Itraconazole on the PK of CHF6001 (Tanimilast)
- Conditions
- Interventions
- First Posted Date
- 2021-02-05
- Last Posted Date
- 2021-05-05
- Lead Sponsor
- Chiesi Farmaceutici S.p.A.
- Target Recruit Count
- 24
- Registration Number
- NCT04739774
- Locations
- 🇧🇪
SGS Life Sciences - Clinical Pharmacology Unit Antwerpen, Antwerp, Belgium
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 474121 in the Blood
- First Posted Date
- 2021-01-20
- Last Posted Date
- 2024-03-08
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 14
- Registration Number
- NCT04716894
- Locations
- 🇩🇪
Humanpharmakologisches Zentrum Biberach, Biberach, Germany
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 706321 in the Blood
- First Posted Date
- 2021-01-19
- Last Posted Date
- 2021-05-06
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 14
- Registration Number
- NCT04714073
- Locations
- 🇩🇪
CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany
A Study to Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the Body
- First Posted Date
- 2021-01-15
- Last Posted Date
- 2021-04-09
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 11
- Registration Number
- NCT04712396
- Locations
- 🇩🇪
Research Site, Berlin, Germany
A Drug Interaction Study of ACH-0145228
- Conditions
- Interventions
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2021-01-14
- Lead Sponsor
- Alexion Pharmaceuticals, Inc.
- Target Recruit Count
- 38
- Registration Number
- NCT04709081
- Locations
- 🇺🇸
Clinical Study Site, Tempe, Arizona, United States
Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation
- First Posted Date
- 2020-12-03
- Last Posted Date
- 2023-04-24
- Lead Sponsor
- Hong Nguyen
- Registration Number
- NCT04652050
- Locations
- 🇺🇸
UPMC, Pittsburgh, Pennsylvania, United States
A Study in Healthy Japanese Men to Test How Different Doses of BI 1323495 Are Tolerated and How Itraconazole Influences the Amount of BI 1323495 in the Blood
- First Posted Date
- 2020-11-06
- Last Posted Date
- 2024-03-27
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 74
- Registration Number
- NCT04619251
- Locations
- 🇯🇵
SOUSEIKAI Sumida Hospital, Tokyo, Sumida-ku, Japan
Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2020-10-28
- Last Posted Date
- 2024-02-23
- Lead Sponsor
- KBP Biosciences
- Target Recruit Count
- 24
- Registration Number
- NCT04606537
- Locations
- 🇺🇸
QPS Missouri, Springfield, Missouri, United States
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GSK3915393 in Healthy Participants and to Evaluate the Interaction Between GSK3915393 and Grapefruit Juice and Itraconazole
- First Posted Date
- 2020-10-27
- Last Posted Date
- 2023-05-09
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 65
- Registration Number
- NCT04604795
- Locations
- 🇬🇧
GSK Investigational Site, London, United Kingdom
A Study of LY3509754 in Healthy Non-Japanese and Japanese Participants
- Conditions
- Interventions
- First Posted Date
- 2020-10-14
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 104
- Registration Number
- NCT04586920
- Locations
- 🇺🇸
Anaheim Clinical Trials, LLC, Anaheim, California, United States
🇺🇸Covance Dallas, Dallas, Texas, United States
Drug Development Updates
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