Itraconazole

Generic Name
Itraconazole
Brand Names
Sporanox, Tolsura
Drug Type
Small Molecule
Chemical Formula
C35H38Cl2N8O4
CAS Number
84625-61-6
Unique Ingredient Identifier
304NUG5GF4
Background

One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.

Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Associated Conditions
Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
Associated Therapies
-
Clinical Trials
Related News

Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy

First Posted Date
2011-10-12
Last Posted Date
2017-04-11
Lead Sponsor
Stanford University
Target Recruit Count
4
Registration Number
NCT01450683
Locations
🇺🇸

Stanford University School of Medicine, Stanford, California, United States

Pharmacokinetics of Itraconazole in Pediatric Cancer Patients

Phase 1
Completed
Conditions
Pediatric, Cancer
Interventions
Drug: Itraconazole
First Posted Date
2011-08-03
Last Posted Date
2013-11-19
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
6
Registration Number
NCT01409018
Locations
🇰🇷

Seoul National University Hospital, Seoul, Chongno-gu, Korea, Republic of

Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases

First Posted Date
2011-04-29
Last Posted Date
2014-12-08
Lead Sponsor
Yonsei University
Target Recruit Count
153
Registration Number
NCT01344681
Locations
🇰🇷

Ajou University Medical Center, Suwon, Korea, Republic of

🇰🇷

Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of

🇰🇷

Samsung Medical Center, Seoul, Korea, Republic of

and more 4 locations

Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis

First Posted Date
2011-03-24
Last Posted Date
2017-03-16
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
100
Registration Number
NCT01321827
Locations
🇮🇳

Postgraduate Institute of Medical Education and Research, Chandigarh, UT, India

Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients

Phase 4
Terminated
Conditions
Graft vs Host Disease
Interventions
Drug: Itraconazole
First Posted Date
2011-01-25
Last Posted Date
2011-01-25
Lead Sponsor
Samsung Medical Center
Target Recruit Count
36
Registration Number
NCT01282879
Locations
🇰🇷

Soonchunhyang University Bucheon Hospital, Bucheon, Kyounggi-do, Korea, Republic of

🇰🇷

Inha University Hospital, Incheon, Korea, Republic of

🇰🇷

Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Korea, Republic of

and more 6 locations

Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis

First Posted Date
2010-12-14
Last Posted Date
2012-02-22
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
31
Registration Number
NCT01259336
Locations
🇮🇳

PGIMER, Chandigarh, Punjab, India

Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection

Phase 4
Completed
Conditions
Invasive Fungal Infection
First Posted Date
2010-09-10
Last Posted Date
2011-10-14
Lead Sponsor
Zhejiang University
Target Recruit Count
150
Registration Number
NCT01198236
Locations
🇨🇳

The First Hospital of Zhejiang Medical Colleage Zhejiang University, Hangzhou, Zhejiang, China

Long-term Versus Short-term Sequential Therapy (Intravenous Itraconazole Followed by Oral Solution) of Itraconazole as Primary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation

First Posted Date
2010-07-13
Last Posted Date
2010-07-26
Lead Sponsor
Guangzhou General Hospital of Guangzhou Military Command
Target Recruit Count
120
Registration Number
NCT01160952
Locations
🇨🇳

Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, China

Pilot Biomarker Trial to Evaluate the Efficacy of Itraconazole in Patients w/ Basal Cell Carcinomas

Phase 2
Completed
Conditions
Basal Cell Carcinoma (BCC)
Skin Cancer
Interventions
Drug: Itraconazole
First Posted Date
2010-04-21
Last Posted Date
2018-11-13
Lead Sponsor
Stanford University
Target Recruit Count
29
Registration Number
NCT01108094
Locations
🇺🇸

Stanford University School of Medicine, Stanford, California, United States

The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants

First Posted Date
2009-11-30
Last Posted Date
2013-08-12
Lead Sponsor
Janssen Korea, Ltd., Korea
Target Recruit Count
203
Registration Number
NCT01021683
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