Cholestyramine
- Generic Name
- Cholestyramine
- Brand Names
- Prevalite, Questran
- Drug Type
- Small Molecule
- Chemical Formula
- -
- CAS Number
- 11041-12-6
- Unique Ingredient Identifier
- 4B33BGI082
- Background
Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
- Indication
Indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Also for the relief of pruritus associated with partial biliary obstruction.
- Associated Conditions
- Atherosclerosis, Primary Hypercholesterolemia, Pruritus
- Associated Therapies
- -
Options for Treating Non-Familial Hypercholesterolemia
Medical Journeys offers clinical resources for physicians and patients, focusing on disease management. Statins are central to lipid management, reducing cholesterol production and LDL levels. Guidelines recommend statins based on ASCVD risk and LDL levels, with additional options like ezetimibe and PCSK9 inhibitors for further LDL reduction. Risk factors include family history, chronic conditions, and specific biomarkers. Statins aim for significant LDL reduction, with effectiveness across ages. Non-statin agents complement therapy, though some like fibrates and niacin offer limited additional benefit.
Company Statement on FDA Advisory Committee Meeting
FDA's GIDAC discussed Intercept's sNDA for OCALIVA for PBC treatment; Intercept disappointed by the committee's vote, emphasizing OCALIVA's clinical benefits. FDA to make final decision by October 15, 2024.
Cholesterol Medications: Managing Levels and Reducing Heart Disease Risk
Lifestyle changes and medications can manage cholesterol levels. Statins are effective for lowering LDL cholesterol and reducing heart disease risk. Other medications include ezetimibe, bile acid sequestrants, PCSK9 inhibitors, and ACLY inhibitors. Consult healthcare professionals for personalized treatment plans and potential side effects.
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.
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