Glyburide
- Generic Name
- Glyburide
- Brand Names
- Diabeta, Glucovance, Glynase, Amglidia
- Drug Type
- Small Molecule
- Chemical Formula
- C23H28ClN3O5S
- CAS Number
- 10238-21-8
- Unique Ingredient Identifier
- SX6K58TVWC
- Background
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ...
- Indication
Glyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.
- Associated Conditions
- Gestational Diabetes Mellitus (GDM), Glycemic Control, Type 2 Diabetes Mellitus
- Associated Therapies
- -
A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus
- Conditions
- Interventions
- First Posted Date
- 2012-03-26
- Last Posted Date
- 2016-11-01
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 108
- Registration Number
- NCT01563120
- Locations
- 🇮🇱
Dep. OB/GYN, Emek Medical Center, Afula, Israel
R230C and C230C Variants of ABCA1 and Glyburide Response
- First Posted Date
- 2011-10-21
- Last Posted Date
- 2014-01-15
- Target Recruit Count
- 85
- Registration Number
- NCT01456650
- Locations
- 🇲🇽
Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, DF, Mexico
Glyburide (RP-1127) for Traumatic Brain Injury (TBI)
- First Posted Date
- 2011-10-18
- Last Posted Date
- 2024-11-11
- Lead Sponsor
- Remedy Pharmaceuticals, Inc.
- Target Recruit Count
- 29
- Registration Number
- NCT01454154
- Locations
- 🇺🇸
UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸University of Maryland Medical Center, Shock Trauma Center, Baltimore, Maryland, United States
🇺🇸University of California, San Diego, San Diego, California, United States
Glyburide and Metformin for Gestational Diabetes Mellitus (GDM)
- Conditions
- Interventions
- First Posted Date
- 2011-04-05
- Last Posted Date
- 2015-02-10
- Target Recruit Count
- 360
- Registration Number
- NCT01329016
- Locations
- 🇺🇸
University of Washington, Seattle, Washington, United States
🇺🇸University of Texas Medical Branch, Galveston, Texas, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Vitamin C Supplementation Plus Hypoglycemic Agents Versus Hypoglycemic Agents Alone in Type 2 Diabetes Mellitus
- First Posted Date
- 2011-03-22
- Last Posted Date
- 2013-09-18
- Lead Sponsor
- Al-Neelain University
- Target Recruit Count
- 50
- Registration Number
- NCT01319734
- Locations
- 🇸🇩
Jaber abo aliz, Khartoum, Sudan
Evaluation of Cissus Verticillata L. Infusion in Controlling Type 2 Diabetes
- First Posted Date
- 2010-06-16
- Last Posted Date
- 2011-11-09
- Lead Sponsor
- Federal University of Paraíba
- Target Recruit Count
- 15
- Registration Number
- NCT01145534
- Locations
- 🇧🇷
Centro de Especialidades Odontologicas, Patos, Paraiba, Brazil
A Study of LY2599506 (Oral Agent Medication: Glucokinase Activator 1) in Type 2 Diabetes Mellitus
- Conditions
- Interventions
- First Posted Date
- 2009-12-10
- Last Posted Date
- 2011-12-02
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 38
- Registration Number
- NCT01029795
- Locations
- 🇪🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Teruel, Spain
Metformin Compared to Glyburide in Gestational Diabetes
- First Posted Date
- 2009-08-26
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 149
- Registration Number
- NCT00965991
- Locations
- 🇺🇸
University of New Mexico Diabetes in Pregnancy Clinic, Albuquerque, New Mexico, United States
Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)
- Conditions
- Interventions
- First Posted Date
- 2009-07-09
- Last Posted Date
- 2015-01-14
- Lead Sponsor
- University of California, San Francisco
- Registration Number
- NCT00935363
Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy
- First Posted Date
- 2009-07-09
- Last Posted Date
- 2011-10-26
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 124
- Registration Number
- NCT00935805
- Locations
- 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil
Drug Development Updates
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