一氧化氮 (Inomax, Kinox, Noxivent +1)

概览

Nitric Oxide is a vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.

作用机制

Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.

适应症

For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure

• Hypoxic Respiratory Failure