Nitric Oxide

Generic Name: Nitric Oxide

Brand Names: Inomax, Kinox, Noxivent, INOmax

Drug Type: Small Molecule

Chemical Formula: NO

CAS Number: 10102-43-9

Unique Ingredient Identifier: 31C4KY9ESH

Background: Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.

Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.

The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.

Indication: For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure

Associated Conditions: Hypoxic Respiratory Failure

Associated Therapies: -

Clinical Trials

Research suggests flexible approach to antiplatelet management after coronary drug-eluting

In patients with coronary drug-eluting stents undergoing non-cardiac surgery, aspirin monotherapy showed no difference in ischemic outcomes or major bleeding compared to no antiplatelet therapy. The ASSURE DES trial, involving 926 patients, found similar rates of primary outcomes and major bleeding, with a slight increase in minor bleeding in the aspirin group. The low event rate suggests a need for further research in higher-risk scenarios.

nature.com

24 years ago

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

Research highlights the role of PARP in cell death, diabetes, and endothelial dysfunction, showing PARP-deficient mice resist diabetes and ischemia. Studies link high glucose to endothelial dysfunction via oxidative stress and NF-κB activation, with potential therapeutic targets in PARP inhibition.

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