屈他维林

概览

Drotaverine is a phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms.

作用机制

Drotaverine is a selective inhibitor of phosphodiesterase 4 (PDE4), which is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP). Inhibition of PDE4 leads to elevated levels of cAMP, leading to smooth muscle relaxation. Recent research showed that low levels of cAMP have been associated with brain tumorigenesis, leading to the investigation of PDE4 inhibitors as potential anticancer agents.

适应症

Drotaverine is used to alleviate gastrointestinal and genitourinary smooth muscle spasms, such as cholecystitis and gallbladder disorders.

• Abdominal Pain caused by Gall Stones
• Abdominal Pain caused by Kidney Stones
• Muscle Spasms
• Spastic Pain
• Spastic Pain caused by Cystitis
• Spastic Pain caused by Funicular Nephritis
• Spastic Pain caused by Gallbladder disorders
• Spastic Pain caused by Physical Examination
• Spastic Pain caused by cholecysitis
• Spastic Pain of the Gastrointestinal Tract