Drotaverine
- Generic Name
- Drotaverine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C24H31NO4
- CAS Number
- 14009-24-6
- Unique Ingredient Identifier
- 98QS4N58TW
- Background
Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). It is a benzylisoquinoline derivative that is structurally related to papaverine, although it displays more potent antispasmodic activities than papaverine. Drotaverine has been used in the symptomatic treatment of various spastic conditions, such as gastrointestinal diseases, biliary dyskinesia, and vasomotor diseases associated with smooth muscle spasms. It also has been investigated in dysmenorrhea, abortion, and augmentation of labour. More recently, drotaverine gained attention in the treatment of benign prostatic hyperplasia, parainfluenza, and avian influenza viruses.
Drotaverine is not approved by the FDA, European Medicines Agency, or Health Canada. It is approved for use in Thailand as oral tablets or intramuscular injections.
- Indication
Drotaverine is used to alleviate gastrointestinal and genitourinary smooth muscle spasms, such as cholecystitis and gallbladder disorders.
- Associated Conditions
- Abdominal Pain caused by Gall Stones, Abdominal Pain caused by Kidney Stones, Muscle Spasms, Spastic Pain, Spastic Pain caused by Cystitis, Spastic Pain caused by Funicular Nephritis, Spastic Pain caused by Gallbladder disorders, Spastic Pain caused by Physical Examination, Spastic Pain caused by cholecysitis, Spastic Pain of the Gastrointestinal Tract
- Associated Therapies
- -
Drotaverine to Shorten the Length of Labor
- Conditions
- Prolonged First Stage of LaborFailure of Cervical Dilation as Antepartum ConditionLabor PainMild Birth Asphyxia, APGAR 4-7
- Interventions
- Drug: PlaceboDrug: Drotaverine
- First Posted Date
- 2012-07-12
- Last Posted Date
- 2013-01-18
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 352
- Registration Number
- NCT01639027
- Locations
- 🇪🇬
Labor at the delivery unit of Ain Shams Maternity Hospital, Abbasiya, Cairo, Egypt
Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae
- Conditions
- Effect of Meperidine or Drotaverine on Effacement and Dilatation of the Cervix During Labor in Full Term Primigravidae
- Interventions
- First Posted Date
- 2010-11-09
- Last Posted Date
- 2010-11-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 200
- Registration Number
- NCT01236651
- Locations
- 🇪🇬
Mahmoud, Cairo, Egypt
Drotaverine in Dysmenorrhoea Treatment
- Conditions
- Dysmenorrhea
- Interventions
- First Posted Date
- 2006-02-16
- Last Posted Date
- 2017-08-08
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 480
- Registration Number
- NCT00292747
- Locations
- 🇭🇺
Sanofi-Aventis, Budapest, Hungary
Drug Development Updates
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