Carglumic acid

Generic Name
Carglumic acid
Brand Names
Carbaglu, Ucedane
Drug Type
Small Molecule
Chemical Formula
C6H10N2O5
CAS Number
1188-38-1
Unique Ingredient Identifier
5L0HB4V1EW
Background

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010.

Indication

For the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood.

Associated Conditions
Acute Hyperammonaemia, Chronic Hyperammonaemia
Associated Therapies
Maintenance therapy
© Copyright 2024. All Rights Reserved by MedPath