Dichloroacetic acid

Generic Name
Dichloroacetic acid
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C2H2Cl2O2
CAS Number
79-43-6
Unique Ingredient Identifier
9LSH52S3LQ
Background

Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness.

DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.

Associated Conditions
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Associated Therapies
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biospace.com
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Saol Therapeutics Announces Submission of New Drug Application (NDA) to the U.S. FDA

Saol Therapeutics submitted an NDA to the FDA for SL1009, Sodium Dichloroacetate Oral Solution, for treating Pyruvate Dehydrogenase Complex Deficiency (PDCD) in children, supported by Phase 3 study results.
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