Dichloroacetic acid
- Generic Name
- Dichloroacetic acid
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C2H2Cl2O2
- CAS Number
- 79-43-6
- Unique Ingredient Identifier
- 9LSH52S3LQ
- Background
Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness.
DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.
- Associated Conditions
- -
- Associated Therapies
- -
Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome
- Conditions
- First Posted Date
- 2003-09-11
- Last Posted Date
- 2005-06-24
- Target Recruit Count
- 35
- Registration Number
- NCT00068913
- Locations
- 🇺🇸
New York Presbyterian Hospital, New York City, New York, United States
Prevention of Dichloroacetate Toxicity
- Conditions
- First Posted Date
- 2002-02-27
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 30
- Registration Number
- NCT00031161
- Locations
- 🇺🇸
University of Florida, Gainesville, Florida, United States
Dichloroacetate Kinetics, Metabolism and Toxicology
- Conditions
- First Posted Date
- 2001-04-19
- Last Posted Date
- 2006-09-04
- Target Recruit Count
- 100
- Registration Number
- NCT00015015
- Locations
- 🇺🇸
Univ. of Florida, Gainesville, Florida, United States
Drug Development Updates
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