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Bacillus calmette-guerin substrain russian BCG-I live antigen is an intravesically-administered live BCG vaccine used to treat papillary urothelial cell carcinoma of the bladder.
Bacillus calmette-guerin substrain russian BCG-I live antigen is an intravesically-administered live BCG vaccine used to treat papillary urothelial cell carcinoma of the bladder.
The precise mechanism through which live BCG vaccines exert antineoplastic activity is unclear. It is likely that instillation of the vaccine into the bladder results in a non-specific immune response, involving both the innate and adaptive immune systems, followed by a local inflammatory response involving a variety of immune cells. BCG itself may exert direct cytotoxic effects on tumor cells, though its primary mechanism of action appears to be via internalization into tumor cells where it stimulates the aforementioned inflammatory pathways.
The live BCG vaccine (substrain Russian BCG-I, i.e. VERITY-BCG) is indicated for adjuvant therapy following transurethral resection of a primary or relapsing superficial papillary urothelial cell carcinoma of the bladder in stages Ta (grade 2 or 3) or T1 (grade 1, 2, or 3), without concomitant carcinoma in situ. It may also be used for stage Ta grade 1 papillary tumors, but only when the risk of recurrence is high (>50%).
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