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Protein S human is a medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy.
Protein S human is a medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy.
Thrombin converts protein C to activated protein C (APC) . Protein S functions as a cofactor for APC and together they proteolytically cleave factor Va and VIIIa . This inhibits the activities of the prothrombinase and tenase complexes respectively and leads to a reduction in thrombin generation. The reduction in thrombin generation suppresses the coagulation cascade preventing additional clotting from occuring. Protein S is suggested to inhibit factors Va and Xa through protein-protein interactions . Protein S is also suggested to inhibit production of factor Xa by the tenase complex by competing for binding to phospholipids via its gamma-carboxyglutamic acid domain. Protein S is thought to exert an anti-inflammatory effect in addition to its anticoagulant properties. The protein S-C4b-binding protein complex is believed to bind to phosphotidylserines on the cell membranes of apoptotic cells and interact with macrophages, signalling them to phagocytose the cell before it can rupture .
For use in the emergency reversal of coagulation factor deficiency in patients recieving vitamin K antagonist therapy . Protein S is administered as part of a cocktail containing several other coagulation factors.
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