Blinatumomab

Generic Name
Blinatumomab
Brand Names
Blincyto
Drug Type
Biotech
Chemical Formula
-
CAS Number
853426-35-4
Unique Ingredient Identifier
4FR53SIF3A
Background

Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker. CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of malignant B-cells. Since b...

Indication

Blinatumomab is indicated for the treatment of adults and children with relapsed or refractory CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL). It is also indicated in adults and children for the treatment of CD19-positive B-cell precursor ALL in first or second complete remission with minimal residual disease (MRD) greater than or equal to...

Associated Conditions
Precursor B-lymphoblastic leukaemia acute, Refractory B-cell precursor acute lymphoblastic leukemia, Relapsed B cell precursor Acute lymphoblastic leukemia
Associated Therapies
-

Clinical Study With Blinatumomab in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-12-05
Last Posted Date
2017-01-06
Lead Sponsor
Amgen Research (Munich) GmbH
Target Recruit Count
25
Registration Number
NCT01741792
Locations
🇩🇪

Universititätsklinikum, Würzburg, Germany

🇩🇪

Universitätsmedizin, Göttingen, Germany

🇩🇪

Universitätsklinikum des Saarlandes, Homburg, Germany

and more 3 locations

Confirmatory Phase II Study of Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL)

Phase 2
Completed
Conditions
Interventions
First Posted Date
2010-09-22
Last Posted Date
2020-02-10
Lead Sponsor
Amgen Research (Munich) GmbH
Target Recruit Count
116
Registration Number
NCT01207388
Locations
🇷🇴

2105 - Institutul Regional de Oncologie, Iasi, Romania

🇦🇹

1107 - Krankenhaus der Elisabethinen, Linz, Austria

🇮🇹

1309 - Azienda Ospedaliera Antonio Cardarelli, Napoli, Italy

and more 72 locations
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