Sulfadoxine-Pyrimethamine

Generic Name: Sulfadoxine-Pyrimethamine

Brand Names: -

Drug Type: -

Chemical Formula: -

CAS Number: -

Unique Ingredient Identifier: -

Indication: 用于防治耐氯喹的恶性疟原虫所致的疟疾。

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Controlled Human Malaria Infection Transmission Model - Phase A

Phase 1

Suspended

Conditions: Malaria,Falciparum

Interventions: Biological: PfSPZ Challenge
Drug: Sulfadoxine-Pyrimethamine
Drug: Piperaquine
Drug: Artemether lumefantrine
Drug: Primaquine

First Posted Date: 2020-02-21

Last Posted Date: 2024-05-23

Lead Sponsor: University of Oxford

Target Recruit Count: 44

Registration Number: NCT04280692

Locations: 🇰🇪
KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya

Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi

Phase 3

Completed

Conditions: Malaria
Pregnancy

Interventions: Drug: dihydroartemisinin-piperaquine
Drug: Sulfadoxine-pyrimethamine

First Posted Date: 2017-01-04

Last Posted Date: 2021-07-26

Lead Sponsor: Kamuzu University of Health Sciences

Target Recruit Count: 602

Registration Number: NCT03009526

Locations: 🇲🇼
Malaria Alert Center, University of Malawi College of Medicine, Liwonde, Malawi

A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women

Phase 4

Conditions: Pregnancy
Infections, Plasmodia
Drug Kinetics
Clinical Efficacy

Interventions: Drug: Azithromycin plus piperaquine phosphate
Drug: Sulfadoxine-pyrimethamine

First Posted Date: 2015-10-15

Last Posted Date: 2015-10-15

Lead Sponsor: Papua New Guinea Institute of Medical Research

Target Recruit Count: 150

Registration Number: NCT02575755

Locations: 🇵🇬
Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea

Package of Interventions After Recovering From Moderate Acute Malnutrition

Not Applicable

Completed

Conditions: Malnutrition

Interventions: Dietary Supplement: Lipid Nutrient Supplement
Drug: Sulfadoxine-pyrimethamine
Drug: Albendazole
Drug: Zinc
Other: Insecticide-treated bednet

First Posted Date: 2015-01-30

Last Posted Date: 2016-11-10

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 1499

Registration Number: NCT02351687

Locations: 🇲🇼
St. Louis Nutrition Project, Blantyre, Malawi

Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren

Phase 3

Completed

Conditions: Healthy

Interventions: Drug: Piperaquine
Drug: Sulfadoxine-pyrimethamine
Drug: Albendazole
Drug: Praziquantel

First Posted Date: 2012-11-07

Last Posted Date: 2014-02-04

Lead Sponsor: Universiteit Antwerpen

Target Recruit Count: 616

Registration Number: NCT01722539

Locations: 🇨🇬
Mokali health area of Biyela health zone, in Kinshasa province., Kinshasa, Kinshasa province, Congo

Chloroquine for Malaria in Pregnancy

Phase 3

Completed

Conditions: Malaria

Interventions: Drug: Sulfadoxine-pyrimethamine
Drug: Chloroquine

First Posted Date: 2011-09-29

Last Posted Date: 2016-12-28

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 900

Registration Number: NCT01443130

Locations: 🇲🇼
Blantyre Malaria Project - Queen Elizabeth Central Hospital, Blantryre, Blantyre, Malawi

Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda

Phase 4

Withdrawn

Conditions: Intermittent Preventive Treatment
Placental Malaria

Interventions: Drug: Sulfadoxine-pyrimethamine

First Posted Date: 2010-08-19

Last Posted Date: 2015-03-05

Lead Sponsor: University of California, San Francisco

Registration Number: NCT01184911

Locations: 🇺🇬
Infectious Disease Research Center, Tororo, Uganda

Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa

Phase 3

Terminated

Conditions: Intermittent Preventive Treatment In Pregnancy (IPTp)

Interventions: Drug: Azithromycin plus chloroquine
Drug: sulfadoxine-pyrimethamine

First Posted Date: 2010-04-13

Last Posted Date: 2015-06-16

Lead Sponsor: Pfizer

Target Recruit Count: 2891

Registration Number: NCT01103063

Locations: 🇹🇿
Bugando Medical Centre, Mwanza, Tanzania
🇲🇼
Zomba Central Hospital, Zomba, Malawi
🇹🇿
Nyamagana District Hospital, Mwanza, Tanzania

and more 6 locations

Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana

Not Applicable

Completed

Conditions: Malaria
Anaemia

Interventions: Drug: Sulfadoxine-pyrimethamine
Drug: Placebo

First Posted Date: 2009-03-06

Last Posted Date: 2017-01-26

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 2485

Registration Number: NCT00857077

Locations: 🇬🇭
Navrongo Health Research Centre, Navrongo, Upper East Region, Ghana

Intermittent Preventive Treatment of Malaria in Schoolchildren

Phase 3

Completed

Conditions: Intermittent Preventive Treatment
Malaria

Interventions: Drug: amodiaquine + sulfadoxine-pyrimethamine
Drug: dihydroartemisinin-piperaquine
Other: Placebo
Drug: sulfadoxine-pyrimethamine

First Posted Date: 2009-02-27

Last Posted Date: 2024-03-21

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 780

Registration Number: NCT00852371

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