Fluocinolone acetonide

Generic Name: Fluocinolone acetonide

Brand Names: Capex, Derma-Smoothe/FS, Derma-smoothe FS, Dermotic, Flac, Iluvien, Neo-synalar, Otixal, Otovel, Retisert, Synalar, Tri-luma, Yutiq

Drug Type: Small Molecule

Chemical Formula: C_₂₄H_₃₀F_₂O_₆

CAS Number: 67-73-2

Unique Ingredient Identifier: 0CD5FD6S2M

Background: Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetoni...

Indication: Fluocinolone acetonide has been used extensively in different medical areas.

-In dermatology, it is extensively used for the relief of inflammatory dermatosis, dermatitis, psoriasis, hypertrophic tissues, keloid tissues and atopic dermatitis.
...

Associated Conditions: Acute Otitis Media (AOM), Allergic Skin Reaction, Atopic Dermatitis, Blisters, Chronic Disease of Skin, Dermatosis, Diabetic Macular Edema (DME), External Hemorrhoid, Fissure;Anal, Friction and Pressure Injuries, Hemorrhoids, Internal, Non-infectious Posterior Uveitis Chronic Uveitis, Otitis Externa, Perianal erythema, Pruritus, Psoriasis of the scalp, Purulent Wounds, Scab, Seborrheic dermatitis of the scalp, Skin Inflammation caused by Bacterial Infections, Skin Inflammation of the ear, Uveitis, Wound Infections, Anal eczema, Bacterial skin infections, Chronic eczematous otitis externa, Corticosteroid-responsive dermatoses

Associated Therapies: Postoperative Care, Perioperative management therapy, Postoperative treatment

Clinical Trials

Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 Mg) Intravitreal Implants Vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

Phase 3

Recruiting

Conditions: Radiation Retinopathy
Visual Impairment

Interventions: Drug: Faricimab
Drug: fluocinolone acetonide

First Posted Date: 2023-05-06

Last Posted Date: 2024-12-05

Lead Sponsor: Jaeb Center for Health Research

Target Recruit Count: 600

Registration Number: NCT05844982

Locations: 🇺🇸
IL Eye and Ear Infirmary-University of Illinois at Chicago, Chicago, Illinois, United States
🇺🇸
Retina Associates of Florida, LLC, Tampa, Florida, United States
🇺🇸
Midwest Eye Institute, Indianapolis, Indiana, United States

and more 13 locations

A Study of YUTIQ® 0.18 mg Intravitreal Implant for the Management of Chronic Non-infectious Uveitis

Recruiting

Conditions: Uveitis
YUTIQ

Interventions: Drug: Yutiq

First Posted Date: 2022-10-25

Last Posted Date: 2024-07-03

Lead Sponsor: Tianjin Medical University

Target Recruit Count: 15

Registration Number: NCT05592717

Locations: 🇨🇳
Tianjin Medical University Eye Hospital, Tianjin, Tianjin, China

Imaging of Uveitis Patients Receiving Injectable Fluocinolone Acetonide Implant

Recruiting

Conditions: Uveitis

Interventions: Drug: Fluocinolone Acetonide

First Posted Date: 2020-04-09

Last Posted Date: 2024-02-15

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 30

Registration Number: NCT04340505

Locations: 🇺🇸
Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, United States

A Non-Randomized, Open-Label, Single Center Phase 4 Study of the Effect and Safety of ILUVIEN® in Chronic Diabetic Macular Edema Patients Considered Insufficiently Responsive to Available Therapies (Laser, Anti-VEGF) With or Without Intravitreal Corticosteroid Therapy

Phase 4

Completed

Conditions: Chronic Diabetic Macular Edema

Interventions: Drug: ILUVIEN

First Posted Date: 2015-06-15

Last Posted Date: 2015-09-16

Lead Sponsor: Alimera Sciences

Target Recruit Count: 16

Registration Number: NCT02472366

A Pilot Study on the Effect and Safety of Iluvien® in Chronic Diabetic Macular Edema Patients

Phase 4

Completed

Conditions: Diabetic Macular Edema

Interventions: Drug: IlUVIEN

First Posted Date: 2015-02-10

Last Posted Date: 2017-03-10

Lead Sponsor: Association for Innovation and Biomedical Research on Light and Image

Target Recruit Count: 12

Registration Number: NCT02359526

Locations: 🇵🇹
Instituto de Retina de Lisboa, Lisboa, Portugal
🇵🇹
Hospital de São João, Porto, Portugal
🇵🇹
Center for Clinical Trials - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal

and more 1 locations

Pilot Study of a Fluocinolone Acetonide Intravitreal Insert (FA-i) to Treat Intermediate-, Posterior-, or Panuveitis

Phase 1

Completed

Conditions: Uveitis Affecting the Posterior Segment

Interventions: Drug: Fluocinolone Acetonide

First Posted Date: 2013-02-01

Last Posted Date: 2019-12-20

Lead Sponsor: Glenn Jaffe

Target Recruit Count: 17

Registration Number: NCT01781936

Locations: 🇺🇸
Duke Eye Center, Durham, North Carolina, United States

Fluocinolone Acetonide in Diabetic Macular Edema (FAME) Extension Study

Phase 3

Completed

Conditions: Diabetic Macular Edema

Interventions: Drug: Fluocinolone Acetonide

First Posted Date: 2011-02-25

Last Posted Date: 2015-05-04

Lead Sponsor: Alimera Sciences

Target Recruit Count: 120

Registration Number: NCT01304706

Fluocinolone Acetonide Intravitreal Inserts for Vein Occlusion in Retina

Phase 2

Terminated

Conditions: Retinal Vein Occlusion
Macular Edema

Interventions: Drug: Fluocinolone Acetonide

First Posted Date: 2008-10-10

Last Posted Date: 2015-05-28

Lead Sponsor: Alimera Sciences

Target Recruit Count: 20

Registration Number: NCT00770770

Locations: 🇺🇸
University of Kentucky Department of Ophthalmology, Lexington, Kentucky, United States
🇺🇸
Cole Eye Institute, Cleveland, Ohio, United States
🇺🇸
Ophthalmic Consultants of Boston, Boston, Massachusetts, United States