Axitinib

Generic Name
Axitinib
Brand Names
Inlyta, Axitinib Accord
Drug Type
Small Molecule
Chemical Formula
C22H18N4OS
CAS Number
319460-85-0
Unique Ingredient Identifier
C9LVQ0YUXG
Background

Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation V...

Indication

Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.

Associated Conditions
Advanced Renal Cell Carcinoma, Advanced Thyroid cancer
Associated Therapies
First Line Chemotherapy
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