Tamoxifen

Generic Name
Tamoxifen
Brand Names
Soltamox
Drug Type
Small Molecule
Chemical Formula
C26H29NO
CAS Number
10540-29-1
Unique Ingredient Identifier
094ZI81Y45
Background

Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations. Tamoxifen is used alone or as an adjuvant in these treatments. Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with anastrozole.

Tamoxifen was granted FDA approval on 30 December 1977.

Indication

Tamoxifen is indicated to treat estrogen receptor positive metastatic breast cancer in adults, as an adjuvant in the treatment of early stage estrogen receptor positive breast cancer in adults, to reduce the risk of invasive breast cancer after surgery and radiation in adult women with ductal carcinoma in situ.

Associated Conditions
Breast Cancer, Contralateral Breast Cancer, Desmoid Tumor, Early Stage Estrogen Receptor (ER) Positive Breast Cancer, Gynecomastia, Invasive Breast Cancer, Ovarian Cancer, Puberty, Precocious, Metastatic Estrogen Receptor Positive Breast Cancer
Associated Therapies
Ovulation induction therapy

Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer

First Posted Date
2009-10-22
Last Posted Date
2015-05-18
Lead Sponsor
Medical College and Hospital Kolkata
Target Recruit Count
256
Registration Number
NCT00999921
Locations
🇮🇳

Department of Surgery, Medical College, Kolkata, Kolkata, West Bengal, India

CYP2D6 Genotype on the Clinical Effect of Tamoxifen

First Posted Date
2009-09-09
Last Posted Date
2009-09-09
Lead Sponsor
Korea University Anam Hospital
Target Recruit Count
922
Registration Number
NCT00973037
Locations
🇰🇷

Korea University Anam Hopital, Seoul, Korea, Republic of

Exemestane (Aromasine) + Tamoxifen - Breast Neo-Adjuvant

Phase 2
Completed
Conditions
First Posted Date
2009-06-12
Last Posted Date
2009-06-12
Lead Sponsor
Institut Claudius Regaud
Target Recruit Count
15
Registration Number
NCT00919399
Locations
🇫🇷

CHU de Toulouse Rangueil, Toulouse, France

🇫🇷

Institut Claudius Regaud, Toulouse, France

Evaluating the Role of the Addition of Ovarian Function Suppression (OFS) to Tamoxifen in Young Women

Phase 3
Conditions
Interventions
First Posted Date
2009-06-03
Last Posted Date
2009-06-16
Lead Sponsor
Korean Breast Cancer Study Group
Target Recruit Count
1234
Registration Number
NCT00912548
Locations
🇰🇷

Department of Surgery, Korea Cancer Center Hospital, Seoul, Korea, Republic of

A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6

Completed
Conditions
Interventions
First Posted Date
2009-05-13
Last Posted Date
2017-08-25
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
121
Registration Number
NCT00900744
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Trial of Concurrent Versus Sequential Tamoxifen With Radiotherapy in Breast Cancer Patients

First Posted Date
2009-05-11
Last Posted Date
2011-08-30
Lead Sponsor
Tata Memorial Hospital
Target Recruit Count
260
Registration Number
NCT00896155
Locations
🇮🇳

Tata Memorial Center, Parel, Mumbai, India

Zoladex Plus Tamoxifen in Breast Cancer

First Posted Date
2009-01-22
Last Posted Date
2011-08-08
Lead Sponsor
Zhejiang Cancer Hospital
Target Recruit Count
100
Registration Number
NCT00827307
Locations
🇨🇳

Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

ATAC - Pharmacokinetics (PK) Sub-Protocol

Phase 3
Completed
Conditions
Interventions
First Posted Date
2008-11-04
Last Posted Date
2009-05-15
Lead Sponsor
AstraZeneca
Target Recruit Count
9358
Registration Number
NCT00784862

ATAC - Quality of Life Sub-Protocol

Phase 3
Completed
Conditions
Interventions
First Posted Date
2008-11-04
Last Posted Date
2009-05-01
Lead Sponsor
AstraZeneca
Target Recruit Count
308
Registration Number
NCT00784680
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