Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg of proteins including surfactant-associated proteins B and C.
Calfactant is approved for use in the United States of America. It is used to prevent or treat respiratory distress syndrome in premature infants with lung surfactant deficiency. Calfactant has been shown to decrease the incidence of respiratory distress syndrome, mortality due to respiratory distress syndrome, and air leaks associated with respiratory distress syndrome in clinical trials. It adsorbs to the air:fluid interface in the lungs and works to reduce surface tension, in a manner similar to endogenous pulmonary surfactant.
用于预防和治疗早产儿呼吸窘迫综合征(RDS)。
Egypt Neonatal Intensive Care Units (NICUs), Ain Shams University Cairo, Abbasia, Egypt, 11517, Cairo, Egypt
University of Illinois, Chicago, Illinois, United States
University of Washington, Seattle, Washington, United States
Children's Hospital of San Antonio (CHofSA), San Antonio, Texas, United States
University of Missouri, Women's and Children's Hospital, Columbia, Missouri, United States
NICU-Pitt County Memorial Hospital, Greenville, North Carolina, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Maria Fareri Children's Hospital, Valhalla, New York, United States
Weill Cornell Medical Center, New York, New York, United States
Royal Columbian Hospital, New Westminster, British Columbia, Canada
Surrey Memorial Hospital, Vancouver, British Columbia, Canada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
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