Overview
Tapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment of adult psoriasis. It is available as a topical cream to be applied to the affected area once daily. Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) produced in Photorhabdus luminescens, a gram-negative bacillus that lives symbiotically with the Heterorhabditis nematodes. In 1959, it was noticed that Heterorhabditis with a high amount of 3,5-dihydroxy-4-isopropylstilbene did not putrefy once dead, thus suggesting its potential anti-inflammatory activity. Tapinarof received initial approval from the FDA in 2022.
Indication
Tapinarof is indicated for the topical treatment of plaque psoriasis in adults.
Associated Conditions
- Psoriasis Vulgaris (Plaque Psoriasis)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2010/04/05 | Phase 2 | Completed | |||
2009/02/05 | Phase 1 | Completed |
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