Donepezil
- Generic Name
- Donepezil
- Brand Names
- Adlarity, Aricept, Namzaric
- Drug Type
- Small Molecule
- Chemical Formula
- C24H29NO3
- CAS Number
- 120014-06-4
- Unique Ingredient Identifier
- 8SSC91326P
- Background
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other ty...
- Indication
Donepezil, administered orally or via transdermal delivery system, is indicated for the treatment of dementia of the Alzheimer's type. It is also available as an extended-release capsule in combination with memantine for the treatment of moderate-to-severe dementia of the Alzheimer's type in patients previously stabilized on 10mg of donepezil hydrochloride o...
- Associated Conditions
- Alzheimer's Disease (AD), Dementia With Lewy Body Disease, Dementia due to Parkinson's disease, Dementia of the Alzheimer's Type, Vascular Dementia (VaD), Moderate Alzheimer's Type Dementia, Severe Alzheimer's Type Dementia
- Associated Therapies
- -
Efficacy and Safety of Donepezil and Sodium Oligomannate in Patients With Mild to Moderate Alzheimer's Disease
- First Posted Date
- 2021-11-10
- Last Posted Date
- 2021-11-10
- Target Recruit Count
- 150
- Registration Number
- NCT05114499
Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture
- Conditions
- Interventions
- First Posted Date
- 2021-10-15
- Last Posted Date
- 2024-05-30
- Target Recruit Count
- 240
- Registration Number
- NCT05078944
- Locations
- 🇨🇳
Shanghai Institute of Acupuncture, Moxibustion and Meridian Organization, Shanghai, China
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
- Conditions
- Interventions
- First Posted Date
- 2021-01-29
- Last Posted Date
- 2024-10-28
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 44
- Registration Number
- NCT04730635
- Locations
- 🇺🇸
Velocity Clinical Research, Hallandale Beach ( Site 0013), Hallandale Beach, Florida, United States
🇦🇺Royal Adelaide Hospital-CALHN Memory Trials ( Site 0031), Adelaide, South Australia, Australia
🇺🇸Insight Clinical Trials ( Site 0020), Beachwood, Ohio, United States
Donepezil Versus Non-drug Treatment in Alzheimer's Disease.
- First Posted Date
- 2020-12-10
- Last Posted Date
- 2023-11-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 240
- Registration Number
- NCT04661280
- Locations
- 🇫🇷
Cognitive Neurology Center, Paris, France
Crossover Pharmacokinetic (PK) Study of 5 and 10 mg Corplex™ Donepezil TDS Compared to 10 mg Aricept® in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2020-11-05
- Last Posted Date
- 2021-05-21
- Lead Sponsor
- Corium, Inc.
- Target Recruit Count
- 60
- Registration Number
- NCT04617782
- Locations
- 🇺🇸
Worldwide Clinical Trials, San Antonio, Texas, United States
The Effect of Donepezil on Wound Healing
- Conditions
- Interventions
- First Posted Date
- 2020-08-10
- Last Posted Date
- 2023-05-22
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 20
- Registration Number
- NCT04505670
- Locations
- 🇺🇸
University of Maryland Shore Medical Center at Easton, Easton, Maryland, United States
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
- First Posted Date
- 2020-06-09
- Last Posted Date
- 2020-12-29
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 360
- Registration Number
- NCT04423276
- Locations
- 🇨🇳
Renji Hospital, Shanghai, Shanghai, China
MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005)
- First Posted Date
- 2020-03-16
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 27
- Registration Number
- NCT04308304
- Locations
- 🇺🇸
ICON ( Site 0003), Salt Lake City, Utah, United States
🇺🇸Woodland Research Northwest, LLC ( Site 0004), Rogers, Arkansas, United States
🇺🇸iResearch Atlanta ( Site 0005), Decatur, Georgia, United States
Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia
- Conditions
- Interventions
- First Posted Date
- 2019-10-22
- Last Posted Date
- 2020-11-05
- Lead Sponsor
- University of Malaga
- Target Recruit Count
- 20
- Registration Number
- NCT04134416
- Locations
- 🇪🇸
Centro de Investigaciones Medico-Sanitarias. University of Malaga, Málaga, Spain
Monitoring Anti-Dementia Drugs by Serum Levels
- First Posted Date
- 2019-10-07
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Zealand University Hospital
- Target Recruit Count
- 132
- Registration Number
- NCT04117178
- Locations
- 🇩🇰
Regionalt Videnscenter for Demens, Roskilde, Region Sjælland, Denmark
Drug Development Updates
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