Overview
First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. Combination use of cinnarizine with other nootropics, such as piracetam resulted in enhanced effect of boosting brain oxygen supply.
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Associated Conditions
- Balance Disorders
- Dizziness
- Motion Sickness
- Nausea
- Peripheral Arterial Disease (PAD)
- Raynaud's Phenomenon
- Vertigo
- Inadequate cerebral circulation
- Peripheral vasculopathy
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/01/17 | Not Applicable | Completed | |||
2010/09/09 | Not Applicable | UNKNOWN | Medical Corps, Israel Defense Force |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| CINNARON 25 TABLET 25 mg | SIN02924P | TABLET | 25 mg | 5/22/1989 | |
| AXCEL CINNARIZINE TABLETS 25 mg | SIN10935P | TABLET | 25 mg | 5/17/1999 | |
| CINNA TABLET 25 mg | SIN08482P | TABLET | 25 mg | 12/16/1995 | |
| STUGERON TABLET 25 mg | SIN01122P | TABLET | 25 mg | 5/13/1988 | |
| CELENID TABLET 25 mg | SIN06513P | TABLET | 25 mg | 8/21/1991 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| TRAVELCIN TAB 25MG | N/A | N/A | N/A | 11/4/2004 | |
| CIN-516 CAP 50MG | N/A | N/A | N/A | 6/28/2002 | |
| R-516 TAB | N/A | N/A | N/A | 2/16/1994 | |
| CARDMANIA TAB 25MG | N/A | N/A | N/A | 11/4/2004 | |
| ANTEROLSERAN CAP 50MG | N/A | N/A | N/A | 7/26/2002 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| CIZIGO cinnarizine 20 mg / dimenhydrinate 40 mg uncoated tablets blister pack | 288565 | Medicine | A | 1/8/2019 | |
| CIZINATE cinnarizine 20 mg / dimenhydrinate 40 mg uncoated tablets blister pack | 288566 | Medicine | A | 1/8/2019 | |
| CIZERE cinnarizine 20 mg / dimenhydrinate 40 mg uncoated tablets blister pack | 288567 | Medicine | A | 1/8/2019 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| CLINADIL CAPSULAS | Laboratorio Stada S.L. | 53105 | CÁPSULA DURA | Medicamento Sujeto A Prescripción Médica | Commercialized |
| DIZINEL 20 MG/40 MG COMPRIMIDOS EFG | 84721 | COMPRIMIDO | Medicamento Sujeto A Prescripción Médica | Commercialized | |
| STUGERON CAPSULAS 75 mg | 53025 | CÁPSULA DURA | Medicamento Sujeto A Prescripción Médica | Commercialized | |
| STUGERON GOTAS 7.50 g/100 ml | 53598 | GOTAS ORALES EN SUSPENSIÓN | Medicamento Sujeto A Prescripción Médica | Not Commercialized |
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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