Diaminopropanol Tetraacetic Acid (DB12362): A Pharmacological and Developmental Review

1. Abstract

Diaminopropanol tetraacetic acid, registered under DrugBank ID DB12362 and CAS number 3148-72-9, is a small molecule identified primarily as a chelating agent. It is also known by synonyms such as Diaminohydroxypropanetetraacetic acid (DHPTA) and DPTA-OH.[1] This compound has reportedly been investigated for therapeutic applications in a range of vascular conditions, including Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease.[1] Chemically, it is classified as a tetracarboxylic acid and an EDTA derivative, possessing multiple functional groups conducive to metal ion chelation.[1] Despite its investigational history in significant cardiovascular pathologies, its current regulatory status is listed as "Approved, Withdrawn".[1] This designation, coupled with a notable scarcity of detailed clinical efficacy, pharmacokinetic, and mechanistic data specific to its vascular applications within publicly accessible databases (as represented by the provided information), presents a complex profile. This report aims to synthesize the available information on Diaminopropanol tetraacetic acid, focusing on its chemical characteristics, investigational background in vascular diseases, potential mechanisms, and the implications of its regulatory status, while critically highlighting the substantial gaps in the existing knowledge base derived from the provided documentation.

2. Introduction to Diaminopropanol Tetraacetic Acid (DB12362)

2.1. Nomenclature and Identifiers