Davesomeran

概览

Davesomeran is an mRNA vaccine in combination with the Moderna COVID-19 vaccine to prevent infection from the Omicron variant of the SARS-CoV-2 virus in people 6 years old or older.

作用机制

The Moderna Bivalent vaccine contains 2 ingredients: davesomeran and elasomeran. They both contains synthetic nucleoside-modified messenger RNA (mRNA) encapsulated in Lipid nanoparticle (LNP) encoding the full-length, pre-fusion stabilized spike protein (S) of SARS-CoV-2, although davesomeran's mRNA specifically targets the BA.4/5 Omicron variants with the L452R and F486V mutations in the S protein. The S protein is a major membrane glycoprotein that can bind to the ACE2 receptor in targeted host cells. Due to its location, the S protein is the main target for most mRNA vaccines due to its immunogenicity.

适应症

Moderna COVID-19 Vaccine, Bivalent (Original and Omicron BA.4/BA.5) is a mixture of 2 mRNA vaccines, davesomeran and elasomeran, and is indicated for active immunization against COVID-19. It may be used in patients between 6 months and 5 years of age as a single booster dose at least 2 months following completion of a primary vaccination series with the monovalent Moderna COVID-19 vaccine. It is also indicated for use in patients ≥6 years of age as a single booster dose following completion of either primary vaccination with any authorized COVID-19 vaccine, or following receipt of the most recent booster dose with any authorized monovalent COVID-19 vaccine.

• Coronavirus Disease 2019 (COVID‑19)