Ranolazine

Generic Name
Ranolazine
Brand Names
Aspruzyo Sprinkle, Ranexa, Ranexa (previously Latixa)
Drug Type
Small Molecule
Chemical Formula
C24H33N3O4
CAS Number
95635-55-5
Unique Ingredient Identifier
A6IEZ5M406
Background

Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drug...

Indication

Ranolazine is indicated for the treatment of chronic angina. It can be used alone or in conjunction with nitrates, beta-blockers, angiotensin receptor blockers, anti-platelet drugs, calcium channel blockers, lipid-lowering drugs, and ACE inhibitors.
...

Associated Conditions
Chronic Angina, Ventricular Arrhythmia
Associated Therapies
-
Clinical Trials
Related News

Ranolazine a Potential New Therapeutic Application

Phase 4
Withdrawn
Conditions
Myocardial Stunning
Interventions
Drug: Placebo
Drug: Ranolazine
First Posted Date
2016-02-22
Last Posted Date
2021-02-25
Lead Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Registration Number
NCT02687269

Does Ranolazine Decrease Biomarkers of Myocardial Damage in Diabetics

First Posted Date
2015-11-23
Last Posted Date
2017-05-17
Lead Sponsor
Walter Reed National Military Medical Center
Registration Number
NCT02611596

Efficacy of Ranolazine in Patients With Chronic Total Occlusions of Coronary Arteries

First Posted Date
2015-04-22
Last Posted Date
2023-03-13
Lead Sponsor
East Carolina University
Registration Number
NCT02423265
Locations
🇺🇸

East Carolina Heart Institute at Vidant Medical Center, Greenville, North Carolina, United States

Ranolazine Mediated PVC Reduction in Ischemic Heart Disease

First Posted Date
2015-02-10
Last Posted Date
2020-01-29
Lead Sponsor
Kent Hospital, Rhode Island
Target Recruit Count
6
Registration Number
NCT02360397
Locations
🇺🇸

Kent Hospital, Warwick, Rhode Island, United States

Ranolazine Among Unrevascularized Chronic Stable Angina Patients

Phase 2
Completed
Conditions
Angina
Interventions
Drug: Sugar pill
Drug: Ranolazine
First Posted Date
2014-10-16
Last Posted Date
2019-08-22
Lead Sponsor
North Florida Foundation for Research and Education
Target Recruit Count
50
Registration Number
NCT02265796
Locations
🇺🇸

North Florida/South Georgia Veterans Health System, Gainesville, Florida, United States

Impact of Ranolazine in Blood Markers in Women With Angina and Metabolic Syndrome

First Posted Date
2014-09-30
Last Posted Date
2020-04-10
Lead Sponsor
University of Florida
Target Recruit Count
33
Registration Number
NCT02252406
Locations
🇺🇸

University of Florida, Jacksonville, Florida, United States

Study of Ranolazine in Myotonia Congenita, Paramyotonia Congenita and Myotonic Dystrophy Type 1

First Posted Date
2014-09-29
Last Posted Date
2019-03-05
Lead Sponsor
Ohio State University
Target Recruit Count
35
Registration Number
NCT02251457
Locations
🇺🇸

The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D

First Posted Date
2014-09-15
Last Posted Date
2016-03-15
Lead Sponsor
Mayo Clinic
Target Recruit Count
5
Registration Number
NCT02239926
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Ranolazine for Diabetic Peripheral Neuropathic Pain (DPNP)

First Posted Date
2014-06-05
Last Posted Date
2017-02-10
Lead Sponsor
Horizons International Peripheral Group
Target Recruit Count
4
Registration Number
NCT02156336
Locations
🇺🇸

Cardiovascular Institute of the South, Lafayette, Louisiana, United States

🇺🇸

Cardiology Associates, Fairhope, Alabama, United States

Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents

Phase 2
Terminated
Conditions
Angina
Interventions
Drug: Sugar pill
Drug: Ranolazine
First Posted Date
2014-05-28
Last Posted Date
2019-06-11
Lead Sponsor
North Florida Foundation for Research and Education
Target Recruit Count
5
Registration Number
NCT02147834
Locations
🇺🇸

North Florida/South Georgia Veterans Health System, Gainesville, Florida, United States

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