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Oxtriphylline is a bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema.
Oxtriphylline is a bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema.
Oxtriphylline is a choline salt of theophylline. After ingestion, theophylline is released from oxytriphylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
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