Prothrombin

Generic Name: Prothrombin

Brand Names: Balfaxar, Beriplex, Kcentra, Octaplex

Drug Type: Biotech

Chemical Formula: -

CAS Number: 9001-26-7

Unique Ingredient Identifier: 8FB1K07F16

Background: Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.

Indication: For use in the emergency reversal of coagulation factor deficiency in patients receiving vitamin K antagonist therapy. Prothrombin is administered as part of a cocktail containing several coagulation factors.

Associated Conditions: Bleeding, Vitamin K antagonist induced major bleeding

Associated Therapies: -

Clinical Trials

Evaluating siRNA Therapy Fitusiran in Combination With Antithrombin Modulation for Hemophilia

At the 66th ASH Annual Meeting, Steven W. Pipe, MD, presented ATLAS-OLE trial data on fitusiran, an siRNA therapeutic targeting antithrombin, showing its effectiveness as a prophylactic agent for hemophilia A and B, reducing breakthrough bleeds by 70% and factor consumption by 64-98%.

Related Clinical Trials:

Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitory Antibodies to Factor VIII or IX

nature.com

3 months ago

Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination

This study explored autoantibodies in COVID-19 vaccine-related AEFIs, comparing them with other AEFIs, healthy donors, and COVID-19-exposed cases. Recruitment followed SWEDEGENE methodology, focusing on vaccines like Comirnaty, Spikevax, and Vaxzevria. Two subsets of samples were analyzed, with autoantibody detection via bead-based and ELISA assays. Positive responses were confirmed by exceeding specific thresholds or functional analyses. Sampling involved heparinized blood, and statistical analyses were conducted using SPSS and Rstudio.

medicalnewstoday.com