Trazodone
- Generic Name
- Trazodone
- Brand Names
- Desyrel, Oleptro
- Drug Type
- Small Molecule
- Chemical Formula
- C19H22ClN5O
- CAS Number
- 19794-93-5
- Unique Ingredient Identifier
- YBK48BXK30
- Background
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibito...
- Indication
Trazodone is indicated for the treatment of major depressive disorder (MDD). It has been used off-label for adjunct therapy in alcohol dependence, and off-label to treat anxiety and insomnia. It may also be used off-label to treat symptoms of dementia, Alzheimer’s disease, schizophrenia, eating disorders, and fibromyalgia due to its effects on various neurot...
- Associated Conditions
- Alcohol Dependency, Alzheimer's Disease (AD), Anxiety, Dementia, Eating Disorders Symptoms, Fibromyalgia, Insomnia, Major Depressive Disorder (MDD), Pain, Inflammatory, Schizophrenia, Moderate to severe pain
- Associated Therapies
- -
The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression
- Conditions
- Interventions
- First Posted Date
- 2019-11-14
- Last Posted Date
- 2020-04-06
- Lead Sponsor
- Chang Gung Memorial Hospital
- Target Recruit Count
- 22
- Registration Number
- NCT04162743
- Locations
- 🇨🇳
Chang Gung Memorial Hospital, Keelung, Keelung, Taiwan
Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.
- Conditions
- Interventions
- First Posted Date
- 2019-09-09
- Last Posted Date
- 2022-05-12
- Lead Sponsor
- Erich Seifritz
- Target Recruit Count
- 54
- Registration Number
- NCT04082806
- Locations
- 🇨🇭
Psychiatric University Hospital, Zürich, ZH, Switzerland
National Adaptive Trial for PTSD Related Insomnia
- First Posted Date
- 2018-09-12
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 774
- Registration Number
- NCT03668041
- Locations
- 🇺🇸
Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama, United States
🇺🇸Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa, Alabama, United States
🇺🇸Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona, United States
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
- Conditions
- Interventions
- First Posted Date
- 2018-05-23
- Last Posted Date
- 2024-02-05
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 126
- Registration Number
- NCT03534284
- Locations
- 🇺🇸
Northwest Kidney Centers, Seattle, Washington, United States
Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient
- Conditions
- Interventions
- First Posted Date
- 2018-05-11
- Last Posted Date
- 2020-02-05
- Target Recruit Count
- 3
- Registration Number
- NCT03522207
- Locations
- 🇨🇦
CHUM, Montréal, Quebec, Canada
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Conditions
- Interventions
- Drug: Tranexamic acid (TXA)Drug: HydrocodoneDrug: labetalolDrug: metforminDrug: nifedipineDrug: oxycodoneDrug: clindamycinDrug: azithromycinDrug: escitalopramDrug: sertralineDrug: CiprofloxacinDrug: ondansetronDrug: DoxycyclineDrug: LevofloxacinDrug: MethylphenidateDrug: CitalopramDrug: SumatriptanDrug: CyclobenzaprineDrug: FurosemideDrug: RosuvastatinDrug: GabapentinDrug: HydrochlorothiazideDrug: HydroxyureaDrug: TrazodoneDrug: TopiramateDrug: ValganciclovirDrug: RemdesivirDrug: VenlafaxineDrug: VerapamilDrug: FluvoxamineDrug: AnakinraDrug: TocilizumabDrug: AmoxicillinDrug: BupropionDrug: BuprenorphineDrug: LevetiracetamDrug: ParoxetineDrug: Duloxetine
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- Duke University
- Target Recruit Count
- 1600
- Registration Number
- NCT03511118
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸Loma Linda University Health, Loma Linda, California, United States
Trazodone Dose Tolerance and APAP Adherence
- First Posted Date
- 2016-10-26
- Last Posted Date
- 2020-05-11
- Lead Sponsor
- Louis Stokes VA Medical Center
- Target Recruit Count
- 45
- Registration Number
- NCT02945644
- Locations
- 🇺🇸
Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, United States
Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury
- Conditions
- Interventions
- First Posted Date
- 2016-10-04
- Last Posted Date
- 2023-11-03
- Lead Sponsor
- John D. Dingell VA Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT02922894
- Locations
- 🇺🇸
John D. Dingell VA Medical Center, Detroit, Michigan, United States
Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder
- Conditions
- Interventions
- First Posted Date
- 2016-03-04
- Last Posted Date
- 2019-07-10
- Lead Sponsor
- University of California, San Diego
- Registration Number
- NCT02699138
- Locations
- 🇺🇸
University of California San Diego, San Diego, California, United States
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
- Conditions
- Interventions
- First Posted Date
- 2016-01-14
- Last Posted Date
- 2021-07-02
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 635
- Registration Number
- NCT02655354
- Locations
- 🇺🇸
Jacobi Medical Center, Bronx, New York, United States
🇺🇸University of Rochester, Rochester, New York, United States
🇺🇸Honor Health, Scottsdale, Arizona, United States
Drug Development Updates
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