Meperidine

Overview

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

Indication

Used to control moderate to severe pain.

Associated Conditions

Severe Pain

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Comparing Prophylactic Intravenous Pethidine and Intrathecal Pethidine in Preventing Post Spinal Shivering in Caesarean Section	2025/01/15	NCT06775431	Phase 3	Recruiting	Alexandria University
Balanced Analgosedation in Bronchoscopy: Propofol/Pethidine Versus Midazolam/Pethidine	2024/12/17	NCT06736938	Phase 4	Not yet recruiting	Fondazione Andrea Cesalpino Arezzo ONLUS
Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic	2024/08/19	NCT06558916	Phase 4	Completed	Ismail Tekin
Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections	2024/07/22	NCT06513806	Phase 4	Not yet recruiting	Ain Shams University
Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery	2024/03/22	NCT06326944	Phase 2	Recruiting	Kasr El Aini Hospital
Ketamine-midazolam As a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.	2023/11/01	NCT06111872	Phase 2	Completed	National University of Malaysia
Prevention of Shivering Associated With Spinal Anesthesia	2023/10/13	NCT06082076	Phase 2	Not yet recruiting	Assiut University
The Effect of Intraoperative Tramadol on Postoperative Opioid	2023/01/25	NCT05696886	Not Applicable	Completed	Mansoura University
Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA	2022/08/12	NCT05499234	Not Applicable	Completed	Medipol University
Erector Spinae Plane Block Versus Quadratus Lumborum Block for Open Renal Surgeries in Children	2022/05/23	NCT05386121	Phase 4	UNKNOWN	Cairo University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
DEMEROL	Physicians Total Care, Inc.	54868-5808	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	50 mg in 1 mL	12/28/2011
DEMEROL	Hospira, Inc.	0409-1179	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	75 mg in 1 mL	4/2/2024
MEPERIDINE HYDROCHLORIDE	Hikma Pharmaceuticals USA Inc.	0641-6054	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	100 mg in 1 mL	1/30/2024
Meperidine Hydrochloride	Physicians Total Care, Inc.	54868-3559	INTRAMUSCULAR	50 mg in 1 mL	5/6/2010
DEMEROL	Hospira, Inc.	0409-1362	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	25 mg in 1 mL	4/2/2024
Meperidine Hydrochloride	Hikma Pharmaceuticals USA Inc.	0054-4595	ORAL	50 mg in 1 1	4/18/2020
MEPERIDINE HYDROCHLORIDE	Hikma Pharmaceuticals USA Inc.	0641-6052	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	25 mg in 1 mL	1/30/2024
MEPERIDINE HYDROCHLORIDE	Hikma Pharmaceuticals USA Inc.	0641-6053	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	50 mg in 1 mL	1/30/2024
DEMEROL	Hospira, Inc.	0409-1180	INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS	100 mg in 1 mL	4/2/2024
Demerol	Validus Pharmaceuticals LLC	30698-337	ORAL	100 mg in 1 1	1/24/2024

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
Pethidine-hameln Solution for Injection 50mg/ml	Siegfried Hameln GmbH	SIN14662P	INJECTION, SOLUTION	50mg	11/14/2014
DBL PETHIDINE HYDROCHLORIDE INJECTION BP 50mg/ml	Siegfried Hameln GmbH	SIN00753P	INJECTION	50 mg/ml	5/4/1988

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
DEMOTHINE SOLUTION FOR INJECTION 100MG/2ML	N/A	JACOBSON MEDICAL (HONG KONG) LIMITED	N/A	N/A	1/25/2024
DEMOTHINE SOLUTION FOR INJECTION 50MG/1ML	N/A	JACOBSON MEDICAL (HONG KONG) LIMITED	N/A	N/A	1/25/2024

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
DBL PETHIDINE HYDROCHLORIDE 100mg/2mL Injection	107387	Pfizer Australia Pty Ltd	Medicine	A	12/15/2004
NOUMED PETHIDINE TABLETS pethidine hydrochloride 50 mg uncoated tablet bottle	397893	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	10/17/2022
PETHIDINE JUNO pethidine injection BP 100mg/2mL ampoule	340377	Juno Pharmaceuticals Pty Ltd	Medicine	A	9/28/2020
DBL PETHIDINE HYDROCHLORIDE 50mg/1mL Injection	107386	Pfizer Australia Pty Ltd	Medicine	A	12/15/2004

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
MEPERIDINE HYDROCHLORIDE INJECTION USP	Sandoz Canada, Inc.	00725765	Solution - Subcutaneous , Intravenous , Intramuscular	50 MG / ML	12/31/1987
MEPERIDINE HCL INJECTION 50MG/ML	hospira healthcare ulc	00497452	Solution - Intravenous , Subcutaneous , Intramuscular	50 MG / ML	12/31/1981
MEPERIDINE HYDROCHLORIDE INJECTION USP	Sandoz Canada, Inc.	00725749	Solution - Intravenous , Subcutaneous , Intramuscular	100 MG / ML	12/31/1988
DEMEROL 100 MG/ML	hospira healthcare ulc	02242006	Solution - Intramuscular , Subcutaneous	100 MG / ML	5/1/2000
DEMEROL 50 MG/ML (MULTIPLE DOSE WITH METACRESOL AS PRESERVATIVE)	hospira healthcare ulc	02242002	Solution - Subcutaneous , Intramuscular	50 MG / ML	12/1/2000
MEPERIDINE HCL INJECTION 10MG/ML	hospira healthcare ulc	00497436	Solution - Intravenous , Subcutaneous , Intramuscular	10 MG / ML	12/31/1981
MEPERIDINE HCL INJECTION 75MG/ML	hospira healthcare ulc	00497460	Solution - Intramuscular , Intravenous , Subcutaneous	75 MG / ML	12/31/1981
MEPERIDINE HYDROCHLORIDE INJECTION USP	ICU Medical Canada Inc	00640409	Solution - Intravenous	10 MG / ML	12/31/1986
DEMEROL 50MG - LIQ IM SC 50MG/ML	sanofi canada, inc.	02137992	Liquid - Subcutaneous , Intramuscular	50 MG / ML	12/31/1944
PETHIDINE INJECTION B.P.	hospira healthcare ulc	02208148	Solution - Intravenous	10 MG / ML	9/24/1998

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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