Beclomethasone Dipropionate

Generic Name
Beclomethasone Dipropionate
Brand Names
Alanase, Beconase, Propaderm, Qnasl, Qvar, Rivanase AQ
Drug Type
Small Molecule
Chemical Formula
C28H37ClO7
CAS Number
5534-09-8
Unique Ingredient Identifier
5B307S63B2
Background

Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to dexamethasone. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is rapidly converted into 17-BMP upon administration. Formulations for oral inhalation, intranasal, and topical use are available for beclomethasone dipropionate. Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray. Due to its anti-inflammatory, antipruritic, and anti-allergy properties, beclomethasone dipropionate is used in various inflammatory conditions, such as asthma, allergic rhinitis, and dermatoses to reduce symptoms. When inhaled, it is proposed that beclomethasone dipropionate remains active locally in the lung without causing significant side effects associated with systemic corticosteroids. Compared to earlier corticosteroids such as dexamethasone and prednisolone, beclomethasone dipropionate is reported to be less irritating to the nasal mucosa with a longer duration of action when administered intranasally.

Indication

糖皮质激素类药。主要用于持续性哮喘的长期治疗。按照支气管哮喘严重程度分级标准,在轻度持续(2级以上)即可使用吸入糖皮质激素治疗;外用适用于对糖皮质激素外用有效的各种非感染性炎症性皮肤病,如亚急性和慢性湿疹、脂溢性皮炎、接触性皮炎、特应性皮炎、局限性神经性皮炎、寻常型银屑病、盘状红斑狼疮、扁平苔癣等。亦可用于常年性变应性鼻炎和季节性变应性鼻炎及血管收缩性鼻炎;亦用于鼻息肉切除术后,预防息肉的再生。

Associated Conditions
Asthma, Bacterial Sinusitis, Chronic Sinusitis, Dermatosis, Fungal skin infection, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Vasomotor Rhinitis, Corticosteroid-responsive dermatoses, Recurrent nasal polyps
Associated Therapies
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Evaluation of Two Doses of QVAR by Breath Operated and Metered Dose Inhalers in Asthmatic Children

Phase 3
Completed
Conditions
First Posted Date
2004-10-11
Last Posted Date
2021-11-23
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
440
Registration Number
NCT00094016
Locations
🇺🇸

NorthEast Medical Research Associates, North Dartmouth, Massachusetts, United States

🇺🇸

The Asthma and Allergy Center, Papillion, Nebraska, United States

🇺🇸

Allergy, Asthma & Dermatology Research Center, Lake Oswego, Oregon, United States

and more 36 locations

Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2003-10-29
Last Posted Date
2021-11-24
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
49
Registration Number
NCT00071552
Locations
🇺🇸

National Jewish Medical and Research Center, Denver, Colorado, United States

Compassionate Use of Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Gastrointestinal Tract

Not Applicable
Completed
Conditions
First Posted Date
2003-03-07
Last Posted Date
2011-03-08
Lead Sponsor
Roswell Park Cancer Institute
Target Recruit Count
51
Registration Number
NCT00055666
Locations
🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

Beclomethasone Plus Prednisone in Treating Patients With Graft-Versus-Host Disease

Phase 3
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-05-30
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Registration Number
NCT00043147
Locations
🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

Preventing Frequent Sinus Infections in HIV-Infected Patients

Phase 2
Withdrawn
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00000752
Locations
🇺🇸

Univ of California / San Diego Treatment Ctr, San Diego, California, United States

🇺🇸

Thomas Jefferson Univ Hosp, Philadelphia, Pennsylvania, United States

🇺🇸

Stanford at Kaiser / Kaiser Permanente Med Ctr, San Francisco, California, United States

and more 7 locations
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