Estriol

Generic Name: Estriol

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₄O_₃

CAS Number: 50-27-1

Unique Ingredient Identifier: FB33469R8E

Background: A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North ...

Indication: Used as a test to determine the general health of an unborn fetus.

Associated Conditions: Cervicitis, Menopausal and Postmenopausal Disorders, Hypoestrogenism

Associated Therapies: Estrogen Replacement Therapy

Clinical Trials

Study to Determine Efficacy & Safety of a Low Concentration Estriol (0.005%) in Postmenopausal Vaginal Atrophy.

Phase 3

Completed

Conditions: Vaginal Atrophy

Interventions: Other: Placebo
Drug: Estriol

First Posted Date: 2020-10-05

Last Posted Date: 2020-12-11

Lead Sponsor: Italfarmaco S.A

Target Recruit Count: 167

Registration Number: NCT04574999

Locations: 🇪🇸
Centre Mèdic Teknon S.L., Barcelona, Catalogna, Spain
🇪🇸
Hospital Universitario Central de Asturias, Oviedo, Spain
🇪🇸
Hospital la Ribera de Alzira, Valencia, Spain

and more 9 locations

A Randomized Controlled Phase 2 Study to Determine Lowest Efficacious Dose of Ovestin in Vulvar and Vaginal Atrophy

Phase 2

Withdrawn

Conditions: Vaginal Atrophy

Interventions: Drug: Placebo
Drug: Estriol

First Posted Date: 2019-11-12

Last Posted Date: 2021-07-23

Lead Sponsor: Aspen USA Inc

Registration Number: NCT04159493

LASER and Radiofrequency and Genitourinary Syndrome of Menopause

Not Applicable

Conditions: Postmenopausal Atrophic Vaginitis
Postmenopausal Symptoms
Genitourinary Symptoms

Interventions: Procedure: LASER
Procedure: Microablative Radiofrequency
Drug: Estriol

First Posted Date: 2019-08-05

Last Posted Date: 2023-09-14

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 195

Registration Number: NCT04045379

Locations: 🇧🇷
Federal University of Sao Paulo - Unifesp, São Paulo, SP, Brazil

Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women

Phase 1

Completed

Conditions: Dyspareunia
Menopause
Sexual Dysfunction

Interventions: Drug: Estriol
Drug: Distal estriol
Drug: Vaginal Gel

First Posted Date: 2017-04-14

Last Posted Date: 2024-10-16

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 125

Registration Number: NCT03116022

Locations: 🇧🇷
Hospital das Clínicas de Ribeirão Preto, Ribeirão Preto, SP, Brazil

Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients

Phase 4

Completed

Conditions: Pelvic Organ Prolapse
Vaginitis Atropic
Endometrial Hyperplasia

Interventions: Drug: Conjugated Estrogen
Drug: Promestriene
Drug: Estriol
Drug: Vaginal Moisturizer - Cream

First Posted Date: 2017-01-26

Last Posted Date: 2019-05-01

Lead Sponsor: Universidade Federal do Paraná

Target Recruit Count: 69

Registration Number: NCT03032848

Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, 0.002%, 0.0008% Estriol Vaginal Gel) for the Treatment of Vaginal Dryness in Postmenopausal Women With Vulvovaginal Atrophy

Phase 2

Completed

Conditions: Vaginal Atrophy

Interventions: Drug: Estriol
Drug: Placebo

First Posted Date: 2016-11-18

Last Posted Date: 2019-09-25

Lead Sponsor: ITF Research Pharma, S.L.U.

Target Recruit Count: 283

Registration Number: NCT02967510

Locations: 🇸🇪
For additional information regarding investigative sites for this trial, contact ITF Research Pharma S.L.U., Stockholm, Sweden
🇭🇺
For additional information regarding investigative sites for this trial, contact ITF Research Pharma S.L.U, Szekesfehervar, Hungary

Vaginal Estriol Before and Vaginal Surgery for Prolapse

Phase 4

Conditions: Genital Prolapse

Interventions: Drug: estriol
Procedure: vaginal surgery

First Posted Date: 2016-09-19

Last Posted Date: 2016-09-19

Lead Sponsor: Salvatore Caruso

Target Recruit Count: 88

Registration Number: NCT02906111

The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis

Phase 1

Conditions: Atrophic Vaginitis

Interventions: Drug: Chinese Herbal Compound Ointment
Drug: Estriol

First Posted Date: 2016-04-11

Last Posted Date: 2016-04-11

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 80

Registration Number: NCT02733731

Locations: 🇨🇳
The First Affiliated Hospital of Sun-yat Sen University, Guangzhou, Guangdong, China

A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women With Early Stage Breast Cancer in Treatment With Aromatase Inhibitor in the Adjuvant Setting

Phase 2

Completed

Conditions: Vaginal Atrophy

Interventions: Drug: Placebo
Drug: estriol

First Posted Date: 2015-04-09

Last Posted Date: 2019-08-05

Lead Sponsor: ITF Research Pharma, S.L.U.

Target Recruit Count: 61

Registration Number: NCT02413008

Locations: 🇸🇪
For additional information regarding investigative sites for this trial, contact ITF Research Pharma S.L.U., Stockholm, Sweden

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition

Phase 2

Conditions: Secondary-progressive Multiple Sclerosis
Primary-progressive Multiple Sclerosis
Relapsing-remitting Multiple Sclerosis

Interventions: Other: Placebo
Drug: estriol
Other: Progestin Placebo
Drug: Norethindrone

First Posted Date: 2011-11-06

Last Posted Date: 2019-11-06

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 64

Registration Number: NCT01466114

Locations: 🇺🇸
The University of Colorado Denver, Aurora, Colorado, United States
🇺🇸
The University of New Mexico, Albuquerque, New Mexico, United States
🇺🇸
The University of Pennsylvania, Philadelphia, Pennsylvania, United States

and more 1 locations

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