MedPath

Estriol

Generic Name
Estriol
Drug Type
Small Molecule
Chemical Formula
C18H24O3
CAS Number
50-27-1
Unique Ingredient Identifier
FB33469R8E

Overview

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.

Background

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.

Indication

Used as a test to determine the general health of an unborn fetus.

Associated Conditions

  • Cervicitis
  • Menopausal and Postmenopausal Disorders
  • Hypoestrogenism

Clinical Trials

FDA Approved Products

Arthcal ESTROGEN
Manufacturer:Beijing JUNGE Technology Co., Ltd.
Route:CUTANEOUS
Strength:0.2 g in 100 mL
Approved: 2025/05/14
NDC:85212-0038

Singapore Approved Products

No Singapore products found for this drug

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