考来替泊 (Colestid)

概览

Colestipol is a bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.

作用机制

Colestipol is a lipid-lowering polymer that binds with bile acids in the intestine forming a complex that is excreted in the feces . This non-systemic action results in a continuous, partial removal of bile acids from the enterohepatic circulation preventing their reabsorption . This increased fecal loss of bile acids due to colestipol hydrochloride administration leads to increased oxidation of cholesterol to bile acids . This results in an increase in the number of hepatic low-density lipoprotein (LDL) receptors, and consequently an increased uptake of LDL and a decrease in serum/plasma beta lipoprotein or total and LDL cholesterol levels . Although hydrochloride produces an increase in the hepatic synthesis of cholesterol in man, serum cholesterol levels fall .

适应症

1.Ⅱa型高脂蛋白血症、冠心病危险性大而控制饮食治疗无效者。本品降低血浆总胆固醇和低密度脂蛋白胆固醇浓度，对血清甘油三酯浓度无影响或使之轻度升高，因此，对单纯甘油三酯升高者无效；2.胆管不完全阻塞所致的瘙痒。

• Primary Hypercholesterolemia