Lomustine
- Generic Name
- Lomustine
- Brand Names
- Ceenu, Gleostine
- Drug Type
- Small Molecule
- Chemical Formula
- C9H16ClN3O2
- CAS Number
- 13010-47-4
- Unique Ingredient Identifier
- 7BRF0Z81KG
- Background
An alkylating agent of value against both hematologic malignancies and solid tumors.
- Indication
For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.
- Associated Conditions
- Metastatic Brain Tumors, Primary Brain Neoplasm, Refractory Hodgkin Lymphoma
Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma
- Conditions
- Glioblastoma, IDH-wildtypeMGMT-Methylated Glioblastoma
- Interventions
- First Posted Date
- 2024-05-17
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- Vastra Gotaland Region
- Target Recruit Count
- 200
- Registration Number
- NCT06419946
A Study with L19TNF in Combination with Lomustine in Patients with Glioblastoma At Progression or Recurrence
- First Posted Date
- 2024-03-28
- Last Posted Date
- 2025-01-24
- Lead Sponsor
- Philogen S.p.A.
- Target Recruit Count
- 90
- Registration Number
- NCT06336291
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
🇺🇸Massachusetts General Hospital (MGH), Boston, Massachusetts, United States
🇺🇸Beth Israel Deaconess Medical Center (BIDMC), Boston, Massachusetts, United States
Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma
- Conditions
- Recurrent Glioblastoma
- Interventions
- Procedure: Biopsy ProcedureProcedure: Biospecimen CollectionProcedure: Magnetic Resonance ImagingProcedure: Surgical Procedure
- First Posted Date
- 2024-03-22
- Last Posted Date
- 2025-04-09
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 184
- Registration Number
- NCT06325683
- Locations
- 🇺🇸
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine, United States
🇺🇸Sutter Auburn Faith Hospital, Auburn, California, United States
🇺🇸Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, United States
The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
- Conditions
- GlioblastomaGlioblastoma MultiformeGlioblastoma, IDH-wildtypeGlioblastoma Multiforme of BrainGlioblastoma Multiforme, AdultRecurrent GlioblastomaAstrocytoma, MalignantAstrocytoma of Brain
- Interventions
- Procedure: Re-resectionRadiation: Re-irradiationProcedure: Experimental therapyOther: Best supportive care
- First Posted Date
- 2024-02-28
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Jasper Gerritsen
- Target Recruit Count
- 464
- Registration Number
- NCT06283927
- Locations
- 🇩🇪
Technical University Munich, Munich, Germany
🇳🇱Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
Lerapolturev (PVSRIPO) in GBM
- Conditions
- Recurrent Supratentorial Glioblastoma
- Interventions
- First Posted Date
- 2023-12-20
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- Darell Bigner
- Target Recruit Count
- 92
- Registration Number
- NCT06177964
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study
- Conditions
- First Progression of Glioblastoma
- Interventions
- Radiation: Reirradiation
- First Posted Date
- 2023-06-15
- Last Posted Date
- 2025-05-21
- Target Recruit Count
- 411
- Registration Number
- NCT05904119
- Locations
- 🇦🇹
A.O Landeskrankenhaus - Innsbruck Universitaetsklinik, Innsbruck, Austria
🇦🇹Kepler University Hospital - Neuromed campus, Linz, Austria
🇦🇹Universitaetsklinikum Wien - AKH unikliniken, Vienna, Austria
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
- Conditions
- GlioblastomaRecurrent GlioblastomaGBM
- Interventions
- First Posted Date
- 2023-06-13
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- CarThera
- Target Recruit Count
- 560
- Registration Number
- NCT05902169
- Locations
- 🇺🇸
John Hopkins University, Baltimore, Maryland, United States
🇺🇸University of California, San Francisco, San Francisco, California, United States
🇦🇹Medizinische Universitaet Innsbruck, Innsbruck, Austria
Golden Halo, Static Magnetic and Electric Field Device, in Recurrent Glioblastoma
- Conditions
- GlioblastomaRecurrent Glioblastoma
- Interventions
- First Posted Date
- 2022-06-08
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- Varun Monga, MD
- Registration Number
- NCT05410301
- Locations
- 🇺🇸
University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
- Conditions
- Childhood Medulloblastoma
- Interventions
- Procedure: Audiometric TestProcedure: Auditory Brainstem ResponseProcedure: Biospecimen CollectionProcedure: Magnetic Resonance ImagingOther: Quality-of-Life AssessmentRadiation: Radiation TherapyOther: Survey Administration
- First Posted Date
- 2022-05-19
- Last Posted Date
- 2025-05-04
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 225
- Registration Number
- NCT05382338
- Locations
- 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸Phoenix Childrens Hospital, Phoenix, Arizona, United States
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States
Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression
- First Posted Date
- 2022-03-31
- Last Posted Date
- 2024-04-08
- Lead Sponsor
- Philogen S.p.A.
- Registration Number
- NCT05304663
Drug Development Updates
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