乐卡地平

概览

Lercanidipine is a calcium channel blocker for the management of hypertension.

作用机制

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

适应症

For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome

• Hypertension
• Mild Hypertension
• Moderate Essential Hypertension