Thiotepa
- Generic Name
- Thiotepa
- Brand Names
- Tepadina, Thiotepa Riemser
- Drug Type
- Small Molecule
- Chemical Formula
- C6H12N3PS
- CAS Number
- 52-24-4
- Unique Ingredient Identifier
- 905Z5W3GKH
Overview
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Background
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Indication
ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.
Associated Conditions
- Adenocarcinoma of the Ovaries
- Breast Adenocarcinoma
- Papillary transitional cell carcinoma of bladder
- Malignant effusion
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2006/09/15 | Phase 1 | Completed | |||
2006/07/27 | Phase 2 | Completed | |||
2006/06/12 | Phase 3 | Active, not recruiting | |||
2006/04/24 | Not Applicable | UNKNOWN | European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma | ||
2006/04/12 | Phase 2 | UNKNOWN | Children's Cancer and Leukaemia Group | ||
2006/03/17 | Not Applicable | Completed | |||
2006/02/24 | Phase 1 | Completed | |||
2005/10/13 | Phase 2 | Completed | |||
2005/09/20 | Phase 1 | Completed | |||
2005/09/16 | Phase 2 | Completed | City of Hope Medical Center |
FDA Approved Products
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EMA Approved Products
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Singapore Approved Products
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China Approved Products
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Australia Approved Products
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