Laronidase
- Generic Name
- Laronidase
- Brand Names
- Aldurazyme
- Drug Type
- Biotech
- CAS Number
- 210589-09-6
- Unique Ingredient Identifier
- WP58SVM6R4
Overview
Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
Background
Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
Indication
For the treatment of mucopolysaccharidosis
Associated Conditions
- Mucopolysaccharidosis Type I (MPS I)
Clinical Trials
FDA Approved Products
Singapore Approved Products
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