Anistreplase
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Anistreplase is a form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
Anistreplase is a form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.
与链激酶相似，主要用于急性心肌梗死的治疗，且疗效较佳。尤适用于发病后入院前给药，在心肌梗死症状出现2小时内给药，3个月内的病死率比出现症状4小时内给药者的病死率下降约50％。其疗效与冠状动脉内给链激酶者相近。
