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Hydroquinone

Generic Name
Hydroquinone
Brand Names
Active 4, Glytone, Melamin, Melamix, Neova Complex Hq Plus, Tri-luma
Drug Type
Small Molecule
Chemical Formula
C6H6O2
CAS Number
123-31-9
Unique Ingredient Identifier
XV74C1N1AE

Overview

Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.

Background

Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.

Indication

Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.

Associated Conditions

  • Acne Vulgaris
  • Melasma
  • Skin hyperpigmentation
  • Moderate Melasma
  • Severe Melasma

FDA Approved Products

Hydro-Q
Manufacturer:Dermavance Pharmaceuticals
Route:TOPICAL
Strength:40 mg in 1 g
Approved: 2023/01/12
NDC:30815-0040
ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEX Chest and Neck
Manufacturer:OMP, INC.
Route:TOPICAL
Strength:40 mg in 1 g
Approved: 2014/06/23
NDC:62032-120
OBAGI C RX system C CLARIFYING SERUM
Manufacturer:Obagi Cosmeceuticals LLC
Route:TOPICAL
Strength:40 mg in 1 mL
Approved: 2019/12/24
NDC:62032-106
Hydroquinone 4%
Manufacturer:Gabar Health Sciences Corp.
Route:TOPICAL
Strength:40 mg in 1 g
Approved: 2023/10/21
NDC:82429-309
HYDROQUINONE 8%.
Manufacturer:Sincerus Florida, LLC
Route:TOPICAL
Strength:8 g in 100 g
Approved: 2019/05/20
NDC:72934-6122

Singapore Approved Products

Obagi Nu-Derm Clear
Manufacturer:Pure Tek Corporation
Form:CREAM
Strength:4%
Online:Yes
Approved: 2008/08/13
Approval:SIN13518P
Obagi Nu-Derm Blender
Manufacturer:Pure Tek Corporation
Form:CREAM
Strength:4%
Online:Yes
Approved: 2008/08/13
Approval:SIN13519P
TRI-LUMA CREAM
Manufacturer:HILL DERMACEUTICALS, INC., G. Production Inc.
Form:CREAM
Strength:40 mg/g
Online:Yes
Approved: 2004/10/19
Approval:SIN12607P

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