Overview
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, Carica papaya and Vasconcellea cundinamarcensis. The enzyme is found to be localized in the skin of papaya, and is collected from slashed unripe papayas as a crude latex. Papain is used in food, pharmaceutical, textile, and cosmetic industries. While it has been used for the treatment of inflammation and pain via topical administration, papain has also shown to have anthelmintic and tooth-whitening properties. Present in over-the-counter mixture products consisting of different digestive enzymes, its active site contains a catalytic diad that plays a role in breaking peptide bonds. Papain is also used as an ingredient in various enzymatic debriding preparations.
Background
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, Carica papaya and Vasconcellea cundinamarcensis. The enzyme is found to be localized in the skin of papaya, and is collected from slashed unripe papayas as a crude latex. Papain is used in food, pharmaceutical, textile, and cosmetic industries. While it has been used for the treatment of inflammation and pain via topical administration, papain has also shown to have anthelmintic and tooth-whitening properties. Present in over-the-counter mixture products consisting of different digestive enzymes, its active site contains a catalytic diad that plays a role in breaking peptide bonds. Papain is also used as an ingredient in various enzymatic debriding preparations.
Indication
No FDA-approved therapeutic indications.
Associated Conditions
- Inflammation
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2020/09/18 | Not Applicable | Completed | Aalborg University | ||
2020/08/17 | Not Applicable | Completed | Aalborg University |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Papain Enteric-coated Tablets | 国药准字H44024821 | 化学药品 | 片剂(肠溶) | 9/18/2020 | |
| Papain Enteric-coated Tablets | 国药准字H46020602 | 化学药品 | 片剂 | 3/24/2020 | |
| 木瓜酶肠溶胶囊 | 国药准字H45021431 | 化学药品 | 胶囊剂 | 8/13/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| ENZYME | 16589 | Medicine | A | 9/20/1991 | |
| Bio-Edge Energy Liquid | 316102 | Medicine | A | 4/3/2019 | |
| NutriVital Professional Digestive Enzyme Balance | 375622 | Medicine | A | 9/30/2021 | |
| Plexus ProBioFit | 353839 | Medicine | A | 1/29/2021 | |
| STRONG'EM capsules | 418353 | Medicine | A | 8/17/2023 | |
| Arborvitae ModeX | 407405 | Medicine | A | 4/6/2023 | |
| ProBioFit | 483565 | Medicine | A | 3/21/2025 | |
| Bio-Edge Energy Tablet | 316050 | Medicine | A | 4/2/2019 | |
| Beauty Collagen + Metabolism Support | 390519 | Medicine | A | 6/16/2022 | |
| BioFlam | 217896 | Medicine | A | 11/29/2013 |