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Lysine

Generic Name
Lysine
Brand Names
Aminosyn II 7 %, Sulfite-free, Aminosyn-PF 7%, Clinimix 2.75/5, Clinimix E 2.75/5, Clinisol 15, Freamine 6.9, Freamine III 10, Hepatamine 8, Nephramine, Olimel, Periolimel, Plenamine, Premasol, Primene, Procalamine 3, Prosol, Travasol 10, Trophamine 10 %
Drug Type
Small Molecule
Chemical Formula
C6H14N2O2
CAS Number
56-87-1
Unique Ingredient Identifier
K3Z4F929H6

Overview

Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Background

Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Indication

Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.

Associated Conditions

  • Weight Loss

FDA Approved Products

CLINIMIX E
Manufacturer:Baxter Healthcare Company
Route:INTRAVENOUS
Strength:159 mg in 100 mL
Approved: 2020/09/21
NDC:0338-1142
CLINIMIX E
Manufacturer:Baxter Healthcare Company
Route:INTRAVENOUS
Strength:290 mg in 100 mL
Approved: 2020/09/21
NDC:0338-1148
CLINIMIX E
Manufacturer:Baxter Healthcare Company
Route:INTRAVENOUS
Strength:464 mg in 100 mL
Approved: 2020/09/21
NDC:0338-0214
Kabiven
Manufacturer:Fresenius Kabi USA, LLC
Route:INTRAVENOUS
Strength:263 mg in 100 mL
Approved: 2023/08/02
NDC:63323-712
CLINIMIX
Manufacturer:Baxter Healthcare Corporation
Route:INTRAVENOUS
Strength:348 mg in 100 mL
Approved: 2021/04/13
NDC:0338-0198

Singapore Approved Products

NUTRIFLEX® OMEGA PLUS EMULSION FOR INFUSION
Manufacturer:B. Braun Melsungen AG
Form:INJECTION, EMULSION
Strength:2.728g/1000ml
Online:Yes
Approved: 2018/04/23
Approval:SIN15468P
PERIOLIMEL N4E Emulsion for Infusion
Manufacturer:Ajinomoto Health & Nutrition North America Inc. (Intermediate), Baxter S.A
Form:EMULSION
Strength:1.99g/L
Online:Yes
Approved: 2023/10/20
Approval:SIN16888P
TROPHAMINE INJECTION 10%
Manufacturer:B BRAUN MEDICAL INC
Form:INJECTION
Strength:0.82 g/100 ml
Online:Yes
Approved: 1994/09/12
Approval:SIN07846P
AMINOPLASMAL B.BRAUN 10% E SOLUTION FOR INFUSION
Manufacturer:B. Braun Melsungen AG
Form:INFUSION, SOLUTION
Strength:8.56g/1000ml
Online:Yes
Approved: 2018/01/23
Approval:SIN15411P
NUTRIFLEX® OMEGA SPECIAL B. BRAUN EMULSION FOR INFUSION
Manufacturer:B. Braun Melsungen AG
Form:INJECTION, EMULSION
Strength:3.980g/1000ml
Online:Yes
Approved: 2023/03/07
Approval:SIN16734P

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