Overview
Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.
Indication
For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
Associated Conditions
- Anemia
- B12 Deficiency Anemia
- Beriberi
- Cardiovascular Heart Disease caused by Thiamine Deficiency
- Folic Acid Deficiency Anemia
- Infantile Beriberi
- Infection
- Iron Deficiency (ID)
- Neuritis caused by Pregnancy
- Secondary anemia
- Thiamine Deficiency
- Vitamin Deficiency
- Wernicke's encephalopathy
- Liver disorders
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/10/21 | Not Applicable | ENROLLING_BY_INVITATION | Shanghai Zhongshan Hospital | ||
2024/03/25 | Early Phase 1 | Recruiting | |||
2024/03/07 | Early Phase 1 | Recruiting | |||
2024/10/30 | Phase 3 | Recruiting | |||
2023/05/03 | N/A | Completed | |||
2021/08/10 | Phase 2 | UNKNOWN | |||
2021/05/20 | Phase 4 | UNKNOWN | Henning Grønbæk | ||
2020/11/23 | Phase 4 | Completed | Sarah Saxena | ||
2020/01/02 | N/A | Completed | |||
2019/10/24 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| AvPAK | 50268-677 | ORAL | 1.84 mg in 1 1 | 4/12/2022 | |
| CarWin Pharmaceutical Associates, LLC | 15370-105 | ORAL | 1.2 mg in 1 1 | 1/10/2024 | |
| Method Pharmaceuticals, LLC | 58657-164 | ORAL | 1.05 mg in 1 1 | 12/9/2023 | |
| Exeltis USA, Inc. | 0642-7473 | ORAL | 1.6 mg in 1 1 | 2/14/2023 | |
| Marnel Pharmaceuticals, Inc. | 0682-3001 | ORAL | 20 mg in 1 1 | 5/2/2014 | |
| Centurion Labs, LLC | 23359-105 | ORAL | 3 mg in 1 1 | 1/22/2024 | |
| PureTek Corporation | 59088-193 | ORAL | 3 mg in 1 1 | 1/11/2023 | |
| BonGeo Pharmaceuticals, Inc. | 52796-174 | ORAL | 1.3 mg in 1 1 | 2/2/2024 | |
| Sandoz Inc | 54643-9023 | INTRAVENOUS | 1.2 mg in 5 mL | 10/28/2016 | |
| Sandoz Inc | 54643-9015 | INTRAVENOUS | 6 mg in 10 mL | 10/28/2016 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| ENZYPLEX TABLET | SIN06211P | ENTERIC COATED TABLET | 10 mg | 5/3/1991 | |
| NUTRIHEALTH NEUROVIT TABLET | SIN10261P | TABLET, FILM COATED | 97 mg | 10/14/1998 | |
| NEUROFORTE TABLET | SIN08700P | TABLET, FILM COATED | 100 mg | 5/8/1996 | |
| NUTRIHEALTH NEUROVIT FORTE TABLET | SIN10260P | TABLET, FILM COATED | 242.50 mg | 10/14/1998 | |
| IBERET-FOLIC-500 TABLET | SIN05447P | TABLET, FILM COATED | 6 mg | 2/19/1991 | |
| NEUROBION INJECTION | SIN06262P | INJECTION | 100 mg/3 ml | 6/21/1991 | |
| VITAMIN B FORTE TABLET | SIN07635P | TABLET, FILM COATED | 250 mg | 2/4/1994 | |
| TAMIPOOL FOR INJECTION | SIN11849P | INJECTION, POWDER, FOR SOLUTION | 3 mg/vial | 3/15/2002 | |
| NEUROGEN-E TABLET | SIN08875P | TABLET, FILM COATED | 300 mg | 8/22/1996 | |
| NEUROSANBE TABLET | SIN11606P | TABLET, FILM COATED | 100 mg | 8/3/2001 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Thiamine Nitrate Tablets | 国药准字H11022484 | 化学药品 | 片剂 | 9/9/2020 | |
| Thiamine Nitrate Tablets | 国药准字H11022479 | 化学药品 | 片剂 | 9/11/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| NEW-PAIN-Q CAP | N/A | N/A | N/A | 6/20/1990 | |
| SUMITON CAPSULE (NEW FORMULA) | N/A | N/A | N/A | 6/17/2014 | |
| BIOCATALIN INJECTABLE SOLN (VET) | N/A | N/A | N/A | 8/9/1984 | |
| CODACIN CAP | N/A | N/A | N/A | 5/21/1998 | |
| CHLORAFORTE CAP | N/A | N/A | N/A | 6/2/1992 | |
| WHARNIS (NEW FORMULA) CAPSULES | N/A | N/A | N/A | 11/29/2013 | |
| MENTA CAP | N/A | N/A | N/A | 12/18/1989 | |
| TENDUM CAP | N/A | N/A | N/A | 8/24/2001 | |
| BETARON CAP | N/A | N/A | N/A | 12/6/1994 | |
| KIN-COLD TABLET | N/A | N/A | N/A | 9/5/1994 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Energy Multi | 453128 | Medicine | A | 6/21/2024 | |
| Cellula-T oral powder jar | 43995 | Hong Sp & Hs | Medicine | A | 4/13/1993 |
| Men's Multi | 326959 | Medicine | A | 12/2/2019 | |
| Super B Complex tablets | 126510 | Medicine | A | 3/28/2006 | |
| BLACKMORES B+C TABLETS | 215811 | Medicine | A | 10/9/2013 | |
| Wealthy Health Bio-Maxi B Excellent Stress Relief Formula with Herbs | 139048 | Medicine | A | 5/21/2007 | |
| BLACKMORES SUPERKIDS MULTI CHEWABLES | 289492 | Medicine | A | 5/30/2017 | |
| MaxN-Fuze Multivitamins | 288444 | Max Health & Living Australia Pty Ltd | Medicine | A | 5/1/2017 |
| Kids Multi | 329564 | Medicine | A | 2/6/2020 | |
| FAB IRON Liquid Iron | 287563 | Medicine | A | 4/6/2017 |
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