MedPath

Thiamine

Generic Name
Thiamine
Brand Names
Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C12H17N4OS
CAS Number
70-16-6
Unique Ingredient Identifier
4ABT0J945J

Overview

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Background

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Associated Conditions

  • Anemia
  • B12 Deficiency Anemia
  • Beriberi
  • Cardiovascular Heart Disease caused by Thiamine Deficiency
  • Folic Acid Deficiency Anemia
  • Infantile Beriberi
  • Infection
  • Iron Deficiency (ID)
  • Neuritis caused by Pregnancy
  • Secondary anemia
  • Thiamine Deficiency
  • Vitamin Deficiency
  • Wernicke's encephalopathy
  • Liver disorders

FDA Approved Products

Multivitamin with Fluoride
Manufacturer:Bryant Ranch Prepack
Route:ORAL
Strength:1.05 mg in 1 1
Approved: 2021/12/30
NDC:63629-1139
Vitrexyl
Manufacturer:PureTek Corporation
Route:ORAL
Strength:3 mg in 1 1
Approved: 2023/01/11
NDC:59088-164
Multi-Vit-Flor
Manufacturer:Cameron Pharmaceuticals
Route:ORAL
Strength:1 mg in 1 1
Approved: 2023/09/18
NDC:42494-434
Prometa
Manufacturer:PureTek Corporation
Route:ORAL
Strength:3 mg in 1 1
Approved: 2023/02/08
NDC:59088-172
Thiamine
Manufacturer:Fresenius Kabi USA, LLC
Route:INTRAVENOUS, INTRAMUSCULAR
Strength:100 mg in 1 mL
Approved: 2019/10/21
NDC:63323-013

Singapore Approved Products

ENZYPLEX TABLET
Manufacturer:PT MEDIFARMA LABORATORIES INC
Form:ENTERIC COATED TABLET
Strength:10 mg
Online:Yes
Approved: 1991/05/03
Approval:SIN06211P
NUTRIHEALTH NEUROVIT TABLET
Manufacturer:HOVID BHD
Form:TABLET, FILM COATED
Strength:97 mg
Online:Yes
Approved: 1998/10/14
Approval:SIN10261P
NEUROFORTE TABLET
Manufacturer:BEACONS PHARMACEUTICALS PTE. LTD.
Form:TABLET, FILM COATED
Strength:100 mg
Online:Yes
Approved: 1996/05/08
Approval:SIN08700P
NUTRIHEALTH NEUROVIT FORTE TABLET
Manufacturer:HOVID BHD, HOVID Bhd.
Form:TABLET, FILM COATED
Strength:242.50 mg
Online:Yes
Approved: 1998/10/14
Approval:SIN10260P
IBERET-FOLIC-500 TABLET
Manufacturer:PT Abbott Indonesia
Form:TABLET, FILM COATED
Strength:6 mg
Online:Yes
Approved: 1991/02/19
Approval:SIN05447P

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