Thiamine

Generic Name
Thiamine
Brand Names
Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C12H17N4OS
CAS Number
70-16-6
Unique Ingredient Identifier
4ABT0J945J
Background

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose meta...

Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Associated Conditions
Anemia, B12 Deficiency Anemia, Beriberi, Cardiovascular Heart Disease caused by Thiamine Deficiency, Folic Acid Deficiency Anemia, Infantile Beriberi, Infection, Iron Deficiency (ID), Neuritis caused by Pregnancy, Secondary anemia, Thiamine Deficiency, Vitamin Deficiency, Wernicke's encephalopathy, Liver disorders
Associated Therapies
Nutritional supplementation, Vitamin supplementation, Dietary supplementation
Clinical Trials
Related News

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

First Posted Date
2016-11-28
Last Posted Date
2022-08-09
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
36
Registration Number
NCT02974257
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Optimum Thiamine Intervention (OpTIn) Trial

Phase 4
Completed
Conditions
Wernicke-Korsakoff Syndrome
Interventions
Drug: Thiamine Hydrochloride
First Posted Date
2016-06-02
Last Posted Date
2019-08-16
Lead Sponsor
Menzies School of Health Research
Target Recruit Count
334
Registration Number
NCT02788552
Locations
๐Ÿ‡ฆ๐Ÿ‡บ

Alice Springs Hospital, Alice Springs, Northern Territory, Australia

Thiamine Supplement in Patients With Severe Hyperthyroidism

Not Applicable
Completed
Conditions
Thyrotoxicosis
Interventions
Drug: Thiamine
First Posted Date
2016-05-10
Last Posted Date
2016-10-04
Lead Sponsor
Ramathibodi Hospital
Target Recruit Count
12
Registration Number
NCT02767245
Locations
๐Ÿ‡น๐Ÿ‡ญ

Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Thiamine as an Adjunctive Therapy in Cardiac Surgery

First Posted Date
2014-12-23
Last Posted Date
2017-03-30
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
64
Registration Number
NCT02322892
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement

First Posted Date
2014-03-14
Last Posted Date
2014-03-14
Lead Sponsor
Chengdu University of Traditional Chinese Medicine
Target Recruit Count
324
Registration Number
NCT02087462
Locations
๐Ÿ‡จ๐Ÿ‡ณ

Chengdu university of Traditonal Chinese Medcine, Chengdu, Sichuan, China

The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Phase 2
Completed
Conditions
Critically Ill
Respiratory Failure
Interventions
Drug: Thiamine
First Posted Date
2013-11-15
Last Posted Date
2017-10-02
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
66
Registration Number
NCT01985685
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

Not Applicable
Completed
Conditions
Acute Respiratory Failure
Interventions
Drug: Thiamine
First Posted Date
2011-10-31
Last Posted Date
2018-01-16
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
20
Registration Number
NCT01462279
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Beth Israel Deaconess Medical Center (BIDMC), Boston, Massachusetts, United States

Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy

Phase 3
Completed
Conditions
Chronic Heart Failure
Interventions
Drug: Thiamine
First Posted Date
2010-05-04
Last Posted Date
2010-12-23
Lead Sponsor
Mashhad University of Medical Sciences
Target Recruit Count
50
Registration Number
NCT01115504
Locations
๐Ÿ‡ฎ๐Ÿ‡ท

Faculty of medicine, Azad university, Shahrood, Semnan, Iran, Islamic Republic of

Thiamine as a Metabolic Resuscitator in Septic Shock

Phase 1
Completed
Conditions
Septic Shock
Interventions
Drug: Thiamine
Drug: D5W
First Posted Date
2010-02-18
Last Posted Date
2017-05-15
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
88
Registration Number
NCT01070810
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure

Not Applicable
Completed
Conditions
Heart Failure
Interventions
Drug: Placebo
Drug: Thiamine
First Posted Date
2008-10-09
Last Posted Date
2011-06-27
Lead Sponsor
Luzerner Kantonsspital
Target Recruit Count
12
Registration Number
NCT00770107
Locations
๐Ÿ‡จ๐Ÿ‡ญ

Kantonsspital Luzern, Luzern, Switzerland

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