Amphotericin B
- Generic Name
- Amphotericin B
- Brand Names
- Abelcet, Ambisome, Amphotec, Fungizone
- Drug Type
- Small Molecule
- Chemical Formula
- C47H73NO17
- CAS Number
- 1397-89-3
- Unique Ingredient Identifier
- 7XU7A7DROE
Overview
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Background
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indication
Used to treat potentially life threatening fungal infections.
Associated Conditions
- Coccidioidomycosis
- Fungal Infections
- Histoplasmosis
- Invasive Aspergillosis
- Invasive Fungal Infections
- Leishmaniasis
- Meningitis, Cryptococcal
- Meningitis, Fungal
- Mucocutaneous Leishmaniasis
- Mycotic endophthalmitis
- Penicillium marneffei infection
- Visceral Leishmaniasis
- Candidal cystitis
- Disseminated Cryptococcosis
- Fungal osteoarticular infections
- Ocular aspergillosis
- Refractory aspergillosis
- Severe Coccidioidomycosis
- Severe Cryptococcosis
- Severe Fungal infection caused by Basidiobolus spp.
- Severe Fungal infection caused by Conidiobolus spp.
- Severe Fungal infection caused by sporotrichosis spp.
- Severe Histoplasmosis
- Severe Mucocutaneous leishmaniasis
- Severe North American blastomycosis
- Severe Systemic candidiasis
Clinical Trials
FDA Approved Products
Singapore Approved Products
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