Chloral hydrate

Generic Name
Chloral hydrate
Brand Names
Nortec
Drug Type
Small Molecule
Chemical Formula
C2H3Cl3O2
CAS Number
302-17-0
Unique Ingredient Identifier
418M5916WG
Background

A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.

Indication

Mainly used as a hypnotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.

Associated Conditions
Alcohol Withdrawal Syndrome, Opioid Withdrawal (Disorder), Postoperative pain, Barbiturate withdrawal
Associated Therapies
Sedative therapy

A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI

First Posted Date
2024-09-23
Last Posted Date
2024-11-25
Lead Sponsor
Ain Shams University
Target Recruit Count
60
Registration Number
NCT06606899
Locations
🇪🇬

Ain shams university hospitals, Cairo, Egypt

An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia

First Posted Date
2023-09-26
Last Posted Date
2024-11-07
Lead Sponsor
Pharmanovia
Target Recruit Count
100
Registration Number
NCT06053840
Locations
🇬🇧

Lindus Health, The Leather Market Weston Street, Bermondsey,, London, United Kingdom

Sedation and Nursing Management in EEG Recording in Children

First Posted Date
2022-08-09
Last Posted Date
2022-08-09
Lead Sponsor
Suleyman Demirel University
Target Recruit Count
180
Registration Number
NCT05492812
Locations
🇹🇷

Suleyman Demirel University, Isparta, Turkey

Dexmedetomidine in Children Having Transthoracic Echocardiography

First Posted Date
2015-08-14
Last Posted Date
2017-07-31
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
279
Registration Number
NCT02523144
Locations
🇨🇳

Shanghai Children's Hospital, Shanghai, China

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children

First Posted Date
2014-07-21
Last Posted Date
2017-11-30
Lead Sponsor
University of Cape Town
Target Recruit Count
194
Registration Number
NCT02195661
Locations
🇿🇦

Red Cross War Memorial Children's Hospital, Cape Town, Western Cape, South Africa

Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam

First Posted Date
2011-07-26
Last Posted Date
2013-06-20
Lead Sponsor
University of Sao Paulo
Registration Number
NCT01402596
Locations
🇧🇷

University of Sao Paulo, Sao Paulo, SP, Brazil

A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams

First Posted Date
2010-12-08
Last Posted Date
2016-05-16
Lead Sponsor
Baylor College of Medicine
Target Recruit Count
90
Registration Number
NCT01255904
Locations
🇺🇸

Texas Childrens Hospital, Houston, Texas, United States

Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2010-06-28
Last Posted Date
2011-06-10
Lead Sponsor
Yonsei University
Target Recruit Count
100
Registration Number
NCT01149226
Locations
🇰🇷

Severance Hospital, Seoul, Korea, Republic of

Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate

First Posted Date
2010-03-10
Last Posted Date
2013-10-25
Lead Sponsor
Federal University of Minas Gerais
Target Recruit Count
25
Registration Number
NCT01083797
Locations
🇧🇷

Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

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