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Carbamazepine

Generic Name
Carbamazepine
Brand Names
Carbatrol, Carnexiv, Epitol, Equetro, Tegretol
Drug Type
Small Molecule
Chemical Formula
C15H12N2O
CAS Number
298-46-4
Unique Ingredient Identifier
33CM23913M
Background

Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.

Indication

Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia. In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures. Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder. Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.

Associated Conditions
Acute Mania, Alcohol Withdrawal Syndrome, Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Mixed manic depressive episode, Pain, Partial Seizures With Secondary Generalization, Restless Legs Syndrome (RLS)

HAIC Plus Lenvatinib and PD-1 Inhibitors Improve Outcomes in Advanced Intrahepatic Cholangiocarcinoma

• A study reveals that hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and PD-1 inhibitors significantly improves outcomes in advanced intrahepatic cholangiocarcinoma (ICC). • The HAIC combination therapy demonstrated extended median overall survival (mOS) and progression-free survival (mPFS) compared to standard systemic chemotherapy for ICC. • The combination therapy also resulted in higher objective response rates and disease control rates, indicating a greater impact on tumor treatment response in advanced ICC patients. • Patients receiving HAIC combination therapy experienced fewer treatment-related adverse events compared to those undergoing systemic chemotherapy, suggesting improved tolerability.
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