Carbamazepine

Generic Name
Carbamazepine
Brand Names
Carbatrol, Carnexiv, Epitol, Equetro, Tegretol
Drug Type
Small Molecule
Chemical Formula
C15H12N2O
CAS Number
298-46-4
Unique Ingredient Identifier
33CM23913M
Background

Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant use...

Indication

Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia. In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures. Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive e...

Associated Conditions
Acute Mania, Alcohol Withdrawal Syndrome, Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Mixed manic depressive episode, Pain, Partial Seizures With Secondary Generalization, Restless Legs Syndrome (RLS)
Associated Therapies
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Efficacy analysis of HAIC combined with lenvatinib plus PD1 inhibitor vs. first-line systemic chemotherapy

Advanced ICC patients typically face rapid disease progression and poor prognosis, with gemcitabine plus cisplatin being the primary chemotherapy regimen. HAIC + L + P treatment showed extended mOS and mPFS, higher ORR and DCR, and reduced intrahepatic tumor diameter compared to systemic chemotherapy. HAIC delivers high drug concentrations to liver lesions, reducing systemic toxicity. Targeted therapy and immunotherapy, such as lenvatinib and PD-1 inhibitors, offer additional benefits. Combination therapies, including HAIC with lenvatinib and PD-1 inhibitors, demonstrated improved tumor remission, increased OS and PFS, and fewer AEs. Further large-sample, randomized controlled trials are needed to validate these findings.
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