Carbamazepine

Generic Name: Carbamazepine

Brand Names: Carbatrol, Carnexiv, Epitol, Equetro, Tegretol

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₂N_₂O

CAS Number: 298-46-4

Unique Ingredient Identifier: 33CM23913M

Background: Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant use...

Indication: Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia. In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures. Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive e...

Associated Conditions: Acute Mania, Alcohol Withdrawal Syndrome, Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Mixed manic depressive episode, Pain, Partial Seizures With Secondary Generalization, Restless Legs Syndrome (RLS)

Associated Therapies: -

Clinical Trials

Effects of Lacosamide on Human Motor Cortex Excitability: a Transcranial Magnetic Stimulation Study

Not Applicable

Completed

Conditions: Healthy Male Volunteers

Interventions: Drug: Placebo
Drug: Carbamazepine
Drug: Lacosamide

First Posted Date: 2011-06-27

Last Posted Date: 2012-08-29

Lead Sponsor: University of Kiel

Target Recruit Count: 18

Registration Number: NCT01382017

Locations: 🇩🇪
Departmenr of Neurology, UKSH Campus Kiel, Kiel, Germany

A Study on The Effect of Multiple Dose Carbamazepine on Single Dose Pharmacokinetics of RO4917838 in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteer

Interventions: Drug: RO4917838
Drug: carbamazepine

First Posted Date: 2011-06-03

Last Posted Date: 2016-11-02

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 16

Registration Number: NCT01365403

Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety Evaluation

Phase 4

Completed

Conditions: Epilepsy

Interventions: Drug: zonisamide
Drug: carbamazepine

First Posted Date: 2010-05-20

Last Posted Date: 2022-01-04

Lead Sponsor: Eisai Korea Inc.

Target Recruit Count: 200

Registration Number: NCT01127256

Locations: 🇰🇷
Seoul National Univ. Bundang Hosp., Bundang, Korea, Republic of
🇰🇷
Dongguk Univ. Ilsan Hosp., Ilsan, Korea, Republic of
🇰🇷
Boramae Medical Center, Seoul, Korea, Republic of

and more 9 locations

Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain

Phase 4

Completed

Conditions: Neuropathic Pain

Interventions: Drug: Carbamazepine

First Posted Date: 2010-03-19

Last Posted Date: 2017-07-13

Lead Sponsor: Novartis

Target Recruit Count: 123

Registration Number: NCT01089855

Locations: 🇲🇦
Novartis Investigational Site, Rabat, Morocco

A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy

Completed

Conditions: Seizures
Convulsions
Epilepsy
Osteopenia
Osteoporosis

Interventions: Drug: Normal control
Drug: Topiramate
Drug: Valproic acid
Drug: Carbamazepine

First Posted Date: 2009-12-11

Last Posted Date: 2013-06-26

Lead Sponsor: Janssen Korea, Ltd., Korea

Target Recruit Count: 140

Registration Number: NCT01030094

Compare the Efficacy of Acupuncture Therapy and Carbamazepine Oral Dosage in Patients With Carpal Tunnel Syndrome by Multiple Excitability Test

Not Applicable

Conditions: Carpal Tunnel Syndrome
Multiple Excitability Test

Interventions: Procedure: Acupuncture
Drug: Carbamazepine

First Posted Date: 2009-08-06

Last Posted Date: 2011-04-12

Lead Sponsor: Taipei Medical University WanFang Hospital

Target Recruit Count: 80

Registration Number: NCT00952432

Locations: 🇨🇳
Taipei Medical University - Wan Fang Hospital, Taipei, Taiwan

Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial Seizures

Phase 3

Completed

Conditions: Epilepsy

Interventions: Drug: Zonisamide
Drug: Carbamazepine

First Posted Date: 2009-02-20

Last Posted Date: 2015-12-24

Lead Sponsor: Eisai Inc.

Target Recruit Count: 295

Registration Number: NCT00848549

The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy

Phase 4

Completed

Conditions: Epilepsy

Interventions: Drug: Lamotrigine/Valproate
Drug: Carbamazepine

First Posted Date: 2008-12-15

Last Posted Date: 2015-07-27

Lead Sponsor: Yonsei University

Target Recruit Count: 207

Registration Number: NCT00807989

Locations: 🇰🇷
Yonsei Medical Center, Seoul, Korea, Republic of

Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression

Not Applicable

Completed

Conditions: Traumatic Brain Injury

Interventions: Drug: Placebo
Drug: Carbamazepine

First Posted Date: 2008-02-22

Last Posted Date: 2022-04-22

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 70

Registration Number: NCT00621751

Locations: 🇺🇸
Carolinas Rehabilitation, Charlotte, North Carolina, United States

Premenstrual Dysphoric Disorder and Antiepileptic Drugs

Completed

Conditions: Epilepsy

Interventions: Drug: Lamotrigine
Other: No Intervention
Drug: Levetiracetam
Drug: Carbamazepine

First Posted Date: 2008-02-11

Last Posted Date: 2018-10-26

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 80

Registration Number: NCT00612235

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸
Newton-Wellesley Hospital, Newton, Massachusetts, United States

Drug Development Updates

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