Nimodipine
- Generic Name
- Nimodipine
- Brand Names
- Nimotop, Nymalize
- Drug Type
- Small Molecule
- Chemical Formula
- C21H26N2O7
- CAS Number
- 66085-59-4
- Unique Ingredient Identifier
- 57WA9QZ5WH
- Background
Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compare...
- Indication
For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.
- Associated Conditions
- Delayed Ischemic Neurological Deficit
- Associated Therapies
- -
Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy
- Conditions
- Interventions
- First Posted Date
- 2021-11-23
- Last Posted Date
- 2022-05-25
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 30
- Registration Number
- NCT05131867
- Locations
- 🇪🇬
Aculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt
🇪🇬Faculty of Medicine,Zagazig University, Zagazig, Zagazig, Elsharkia,egypt, Egypt
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
- Conditions
- Interventions
- First Posted Date
- 2021-06-11
- Last Posted Date
- 2022-05-25
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 20
- Registration Number
- NCT04923659
- Locations
- 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
- Conditions
- Interventions
- First Posted Date
- 2020-12-02
- Last Posted Date
- 2023-10-19
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 30
- Registration Number
- NCT04649398
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Stellate Ganglion Block as Adjuvant Therapy to ca Channel Blocker
- Conditions
- Interventions
- First Posted Date
- 2019-09-24
- Last Posted Date
- 2023-06-13
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 40
- Registration Number
- NCT04100824
- Locations
- 🇪🇬
ِAssiut University Hospital, Assiut, Egypt
Measuring Blood Flow in the Brain After Epileptic Activity
- Conditions
- Interventions
- First Posted Date
- 2019-07-22
- Last Posted Date
- 2023-11-18
- Lead Sponsor
- Rijnstate Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT04028596
- Locations
- 🇳🇱
Rijnstate Hospital, Arnhem, Gelderland, Netherlands
Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning
- Conditions
- Interventions
- First Posted Date
- 2019-04-23
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- University of Edinburgh
- Target Recruit Count
- 3243
- Registration Number
- NCT03925025
- Locations
- 🇧🇩
Chattogram Medical College Hospital, Chittagong, Bangladesh
🇧🇩Jashore Medical College Hospital, Jessore, Bangladesh
🇧🇩Shaheed Ziaur Rahman Medical College, Bogra, Silimpur, Bangladesh
Cognitive Effects of Nimodipine in Patients With Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2018-09-14
- Last Posted Date
- 2023-06-23
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 18
- Registration Number
- NCT03671525
- Locations
- 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States
🇺🇸Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
RCVS: The Rational Approach to Diagnosis and Treatment
- First Posted Date
- 2017-05-12
- Last Posted Date
- 2019-09-18
- Lead Sponsor
- Johns Hopkins University
- Registration Number
- NCT03150524
- Locations
- 🇺🇸
Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
🇺🇸Johns Hopkins Hospital, Baltimore, Maryland, United States
Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases
- Conditions
- First Posted Date
- 2016-12-13
- Last Posted Date
- 2019-03-26
- Target Recruit Count
- 25
- Registration Number
- NCT02991157
- Locations
- 🇮🇳
NIMHANS, Bengaluru, India
Nimodipine for Treating Acute Massive Cerebral Infarction
- First Posted Date
- 2014-09-25
- Last Posted Date
- 2018-05-01
- Lead Sponsor
- Fengtian Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT02248233
Drug Development Updates
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