Novartis has halted the phase 3 STIMULUS-MDS2 trial of sabatolimab, a Tim3-targeting drug, for treating myelodysplastic syndromes (MDS) due to not meeting its primary endpoint. The decision reflects a strategic shift to prioritize other projects within Novartis' portfolio. This development marks a significant setback in the race to bring a Tim3-targeting therapy to market, amidst broader challenges in the field.