Lotilaner
- Generic Name
- Lotilaner
- Brand Names
- Xdemvy
- Drug Type
- Small Molecule
- Chemical Formula
- C20H14Cl3F6N3O3S
- CAS Number
- 1369852-71-0
- Unique Ingredient Identifier
- HEH4938D7K
Overview
Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals. Lotilaner consists of two enantiomers: the S-enantiomer is active in vivo, while the R-enantiomer is reported to exhibit low biological activity. The active ingredient found in drug products of lotilaner is the S-enantiomer. On July 25, 2023, lotilaner was approved by the FDA for the treatment of Demodex blepharitis, making it the first and only approved therapeutic for this condition.
Background
Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals. Lotilaner consists of two enantiomers: the S-enantiomer is active in vivo, while the R-enantiomer is reported to exhibit low biological activity. The active ingredient found in drug products of lotilaner is the S-enantiomer. On July 25, 2023, lotilaner was approved by the FDA for the treatment of Demodex blepharitis, making it the first and only approved therapeutic for this condition.
Indication
Lotilaner is indicated for the treatment of Demodex blepharitis.
Associated Conditions
- Demodex Blepharitis
Clinical Trials
FDA Approved Products
Singapore Approved Products
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