Miltefosine
- Generic Name
- Miltefosine
- Brand Names
- Impavido
- Drug Type
- Small Molecule
- Chemical Formula
- C21H46NO4P
- CAS Number
- 58066-85-6
- Unique Ingredient Identifier
- 53EY29W7EC
- Background
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and is only indica...
- Indication
For the treatment of mucosal (caused by Leishmania braziliensis), cutaneous (caused by L. braziliensis, L. guyanensis, and L. panamensis), and visceral leishmaniasis (caused by L. donovani). In comparing Leishmania drug susceptibility, it has been found that L. donovani is the most susceptible to miltefosine while L. major is the least susceptible. Off-label...
- Associated Conditions
- Cutaneous Leishmaniasis, Mucocutaneous Leishmaniasis, Specific infections by free-living amoebae, Visceral Leishmaniasis
- Associated Therapies
- -
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